Complications after prostate biopsies in men on active surveillance and its effects on receiving further biopsies in the Prostate cancer Research International: Active Surveillance (PRIAS) study

BJU International
Leonard P BokhorstAntti Rannikko

Abstract

To study the risk of serial prostate biopsies on complications in men on active surveillance (AS) and determine the effect of complications on receiving further biopsies. In the global Prostate cancer Research International: Active Surveillance (PRIAS) study, men are prospectively followed on AS and repeat prostate biopsies are scheduled at 1, 4, and 7 years after the diagnostic biopsy, or once yearly if prostate-specific antigen-doubling time is <10 years. Data on complications after biopsy, including infection, haematuria, haematospermia, and pain, were retrospectively collected for all biopsies taken during follow-up in men from several large participating centres. Generalised estimating equations were used to test predictors of infection after biopsy. Competing risk analysis was used to compare the rates of men receiving further biopsies between men with and without previous complications. In all, 2 184 biopsies were taken in 1 164 men. Infection was reported after 55 biopsies (2.5%), and one in five men reported any form of complication. At multivariable analysis, the number of previous biopsies was not a significant predictor of infection (odds ratio 1.04, 95% confidence interval 0.76-1.43). The only significant predictor...Continue Reading

References

May 29, 2007·European Urology·Roderick C N van den BerghChris H Bangma
Sep 29, 2011·The Journal of Urology·Stacy LoebEdward M Schaeffer
Nov 20, 2012·European Urology·Meelan BulMonique J Roobol
Jun 22, 2013·European Urology·Stacy LoebYair Lotan
Dec 17, 2014·European Urology·Ivo G SchootsCaroline M Moore
Jan 28, 2015·JAMA : the Journal of the American Medical Association·M Minhaj SiddiquiPeter A Pinto
Mar 15, 2015·Urologia Internationalis·Michael I KoganKurt G Naber
Mar 17, 2015·European Urology·Alan J Wolfe, Linda Brubaker

❮ Previous
Next ❯

Citations

Dec 3, 2016·The Journal of Urology·Stacy Loeb
Jul 2, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshiyuki KakehiUNKNOWN committee for establishment of the evidenced-based clinical practice guideline for prostate cancer of the Japanese Urologica
Dec 28, 2017·PloS One·Juho T EineluotoAntti Rannikko
Aug 16, 2016·BJU International·Behfar Ehdaie
Feb 16, 2019·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Alessandro AntonelliAngelo Porreca
Jun 27, 2018·World Journal of Urology·Olivia LodeizenJean de la Rosette
Aug 8, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Johan Vad-NielsenAnders Lade Nielsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.