Complications and adverse outcomes in pregnancy and childbirth among women who conceived by assisted reproductive technologies: a nationwide birth cohort study of Japan environment and children's study

BMC Pregnancy and Childbirth
Chie NagataJapan Environment & Children’s Study Group

Abstract

Although pregnancies conceived by assisted reproductive technology (ART) have a higher risk of maternal/perinatal complications, the overall risk of adverse outcomes necessitating advanced obstetric care has not been closely examined. The present study aimed to assess and compare the risk of maternal/perinatal complications and adverse outcomes in pregnancy and childbirth conceived by ART with those conceived naturally. This study was conducted as a part of the Japan environment and children's study (JECS), an ongoing nationwide birth cohort study in Japan. The risk of maternal/perinatal complications and adverse outcomes was assessed by mode of conception (natural conception, ovulation induction [OI] without ART, conventional in vitro fertilization and embryo transfer [IVF-ET], or intracytoplasmic sperm injection [ICSI]) using logistic regression and generalized estimating equations controlling for potential confounders. The final dataset included women who conceived naturally (N = 90,506), by OI without ART (N = 3939), by conventional IVF-ET (N = 1476), and by ICSI (N = 1671). Compared with women who conceived naturally, those who conceived by conventional IVF-ET were at higher risk of placenta previa (adjusted OR 2.90 [95% C...Continue Reading

References

May 19, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·E Esh-BroderD Hochner Celnikier
Jul 21, 2011·Human Reproduction·Antonina SazonovaChristina Bergh
Apr 2, 2013·The Cochrane Database of Systematic Reviews·Zohra S LassiZulfiqar A Bhutta
Apr 12, 2013·American Journal of Epidemiology·Takeo FujiwaraIchiro Kawachi
Jan 15, 2014·BMC Public Health·Toshihiro KawamotoUNKNOWN Working Group of the Epidemiological Research for Children’s Environmental Health
Feb 5, 2014·Journal of Assisted Reproduction and Genetics·Kazumi TakeshimaTetsuro Sakumoto
Feb 22, 2014·BMC Pregnancy and Childbirth·Yoshihiro MiyakeMasashi Arakawa
Dec 10, 2015·Obstetrics and Gynecology·Angela S MartinSheree L Boulet
Feb 9, 2016·Obstetrics and Gynecology·Candice BelanoffJudy E Stern
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Nov 3, 2017·Journal of Epidemiology·Takehiro MichikawaUNKNOWN Japan Environment and Children’s Study Group
Oct 7, 2018·American Journal of Perinatology·Nicole E MarshallJonathan M Snowden

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Citations

Jun 20, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Itai GatJigal Hass
Sep 13, 2020·Orphanet Journal of Rare Diseases·Wakako YoshiokaMadoka Mori-Yoshimura
Nov 24, 2020·Clinical and Experimental Reproductive Medicine·Ruchita ShandilyaPradyumna Kumar Mishra
Aug 26, 2019·Journal of Gynecology Obstetrics and Human Reproduction·M AmouyalB Courbiere
Apr 17, 2021·Reproductive Biology·Meng XiangYuan Ma
Sep 3, 2021·Journal of Psychosomatic Obstetrics and Gynaecology·Michael K SimoniKimberly Ann Yonkers

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Methods Mentioned

BETA
cesarean section
hysterectomy

Software Mentioned

SAS
JECS

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