Complications and cancer rates in spine fusion with recombinant human bone morphogenetic protein-2 (rhBMP-2)

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Julia VavkenStefan Schaeren

Abstract

To quantitatively synthesize the available best evidence for general complications, heterotopic ossification (HO), retrograde ejaculation, cervical swelling, and cancer rates with the use of rhBMP-2 in lumbar and cervical spine fusion. We conducted an online search for relevant controlled trials and extracted data on the abovementioned endpoints. Studies were eligible for inclusion if they reported on spinal fusion with rhBMP-2 in humans. Publication bias and heterogeneity were assessed mathematically. These data were synthesized in a meta-analysis using DerSimonian-Laird random effects modeling to calculate pooled odds ratios. We identified 26 studies reporting on a total of 184,324 patients (28,815 experimental, 155,509 controls) with a mean age of 51.1 ± 1.8 years. There was a significantly higher risk of general complications with rhBMP-2 compared to iliac crest bone graft (ICBG) with an odds ratio (OR) of 1.78 (95 %CI 1.20-2.63), (p = 0.004). The odds ratio for HO was 5.57 (95 %CI 1.90-16.36), (p = 0.002), for retrograde ejaculation 3.31 (95 %CI 1.20-9.09), (p = 0.020), and for cervical swelling 4.72 (95 %CI 1.42-15.67), (p = 0.011), all significantly higher in the rhBMP-2 group. The pooled odds ratio for new onset of tumo...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Oct 24, 2002·Journal of Spinal Disorders & Techniques·J Kenneth BurkusThomas A Zdeblick
Sep 15, 2004·The Spine Journal : Official Journal of the North American Spine Society·Regis W HaidJ Kenneth Burkus
Mar 28, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rahul VaidyaClifford M Les
May 8, 2007·The Spine Journal : Official Journal of the North American Spine Society·Paul J SlosarJames Reynolds
Nov 6, 2007·The Spine Journal : Official Journal of the North American Spine Society·Glenn Robin Buttermann
Mar 3, 2009·Clinical Orthopaedics and Related Research·Patrick Vavken, Ronald Dorotka
May 29, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jeffrey A RihnTodd J Albert
Jun 2, 2009·The Spine Journal : Official Journal of the North American Spine Society·Jeffrey A RihnTodd J Albert
Jun 3, 2009·The Journal of Bone and Joint Surgery. American Volume·John R DimarLeah Y Carreon
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Kevin S CahillElizabeth B Claus
Jul 4, 2009·The Spine Journal : Official Journal of the North American Spine Society·Paul Klimo, Michael W Peelle
Aug 27, 2010·The Spine Journal : Official Journal of the North American Spine Society·Richard J MannionMartin J Wood
Aug 28, 2010·The Spine Journal : Official Journal of the North American Spine Society·Ryan D MuchowPaul A Anderson
Dec 15, 2010·Epidemiology·David MoherJennifer Tetzlaff
Feb 8, 2011·The Spine Journal : Official Journal of the North American Spine Society·Tomislav SmoljanovicIvan Bojanic
May 27, 2011·The Spine Journal : Official Journal of the North American Spine Society·Eugene J CarrageeGaetano J Scuderi
Apr 5, 2012·Spine·Emily M LindleyVikas V Patel
Oct 27, 2012·The Spine Journal : Official Journal of the North American Spine Society·Garet C ComerEugene J Carragee
Dec 4, 2012·Journal of Neurosurgery. Spine·Christopher I Shaffrey, Justin S Smith
Jun 13, 2013·Neurosurgery·Shivanand P LadMaxwell Boakye
Aug 27, 2013·The Spine Journal : Official Journal of the North American Spine Society·Martin F HoffmannDebra L Sietsema
Sep 6, 2013·The Journal of Bone and Joint Surgery. American Volume·Eugene J CarrageeBranko Kopjar
Sep 6, 2013·The Journal of Bone and Joint Surgery. American Volume·Addisu MesfinKeith H Bridwell
Sep 14, 2013·The Spine Journal : Official Journal of the North American Spine Society·Bradley K WeinerEugene J Carragee
Sep 14, 2013·The Spine Journal : Official Journal of the North American Spine Society·Kern SinghMiguel A Pelton

❮ Previous
Next ❯

Citations

Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Joseph G LyonsSilvia Minardi
May 11, 2016·Surgical and Radiologic Anatomy : SRA·S Le PapeJ-M Vital
Mar 11, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Gregory W PoormanPeter G Passias
May 21, 2018·Biomolecular Concepts·Justin C KennonSadanand Fulzele
Oct 30, 2020·Frontiers in Bioengineering and Biotechnology·Ben WanDafu Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.