Complications and discomfort after research bronchoscopy in the MicroCOPD study.

BMJ Open Respiratory Research
Elise Orvedal LeitenRune Nielsen

Abstract

Data on discomfort and complications from research bronchoscopy in chronic obstructive pulmonary disease (COPD) and asthma is limited. We present complications and discomfort occurring within a week after bronchoscopy, and investigate personal and procedural risk factors. 239 subjects with COPD, asthma or without lung disease underwent research bronchoscopies as part of a microbiome study of the lower airways (the MicroCOPD study). Bronchoscopy was done in the supine position with oral scope insertion with the option of light conscious alfentanil sedation. Sampling consisted of protected specimen brushes, bronchoalveolar lavage, small volume lavage and for some, endobronchial biopsies. Bleeding, desaturation, cough, haemodynamic changes, dyspnoea and other events that required an unplanned intervention or early termination of bronchoscopy were prospectively recorded. Follow-up consisted of a telephone interview where subjects rated discomfort and answered questions about fever sensation and respiratory symptoms in the week following bronchoscopy. An unplanned intervention or early termination of bronchoscopy was required in 25.9% of bronchoscopies. Three subjects (1.3%) experienced potentially severe complications, of which all...Continue Reading

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Citations

Feb 7, 2021·NPJ Biofilms and Microbiomes·Kristopher OpronYvonne J Huang
Jan 13, 2021·Chest·Karina A SerbanRussell P Bowler

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Methods Mentioned

BETA
sedation
bronchoalveolar lavage
biopsy
biopsies
bronchoalveolar
lavage

Software Mentioned

R
Stata

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