Complications and Effects of Dorsal Root Ganglion Stimulation in the Treatment of Chronic Neuropathic Pain: A Nationwide Cohort Study in Denmark.

Neuromodulation : Journal of the International Neuromodulation Society
Mattias HoranMorten Rune Blichfeldt-Eckhardt

Abstract

Dorsal root ganglion (DRG) stimulation is a novel treatment of chronic neuropathic pain and has been shown to be efficacious across several case reports and randomized trials. However, long-term follow-up is limited, as are reports of complication rates. This study presents efficacy and complications for patients treated with DRG stimulation. We performed an observational, multicenter cohort study of all patients in Denmark implanted with FDA-approved DRG stimulation systems to treat chronic, neuropathic pain between 2014 and 2018. Follow-up period was one to three years. Forty-three patients underwent trial DRG stimulation; 33 were subsequently fully implanted. Pain location: 58% lower extremity; 21% upper extremity; 21% thoracic/abdominal. At the end of the observation period, 58% of fully implanted patients were still implanted; 42% had fully functional systems. In these patients, average Numerical Rating Scale (NRS)-score of pain was reduced from 6.8 to 3.5 (p = 0.00049) and worst NRS-score was reduced from 8.6 to 6.0 (p = 0.0039) at 12 months follow-up. Pain Catastrophizing Score was reduced from 32 to 15 (p = 0.0039). Thirteen patients experienced complications related to defect leads (39% of implanted systems). In four p...Continue Reading

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Citations

Sep 7, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Timothy Lubenow, Harold Nijhuis
Feb 27, 2021·Journal of Pain Research·Natalie StrandChristopher Wie
Jun 20, 2021·Pain Practice : the Official Journal of World Institute of Pain·Kenneth B ChapmanJan Willem Kallewaard
Jul 27, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Kevin HinesAshwini Sharan
Jul 31, 2021·Pain Practice : the Official Journal of World Institute of Pain·Kenneth B ChapmanAjax Yang
Oct 1, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Mattias Horan, Morten Rune Blichfeldt-Eckhardt

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