Complications and visual prognosis in children with aniridia

Journal of Pediatric Ophthalmology and Strabismus
Helena LeeMichael O'Keefe

Abstract

To characterize the ophthalmological findings, assess surgical outcomes, and review visual outcomes in aniridia. A retrospective case review was performed and data were collected, including patient demographics, incidence of aniridia-associated keratopathy, glaucoma, cataract, retinal breaks or detachments, optic nerve hypoplasia, macular hypoplasia, poor vision, and nystagmus. All outcomes from surgery, including penetrating keratoplasty, trabeculectomy, Ahmed valve insertion, and cataract extraction, were recorded. Six children (12 eyes) had corneal abnormalities, 4 had optic nerve hypoplasia, 9 had nystagmus, and 2 had retinal detachments. Four patients (7 eyes) required penetrating keratoplasty. Five patients (9 eyes) developed glaucoma and only 1 of the 4 trabeculectomies performed succeeded. Of the 6 Ahmed valve procedures performed, all succeeded in maintaining a satisfactory intraocular pressure but some required needling and 5-fluorouracil. Eight patients developed cataract and 7 required surgery. Visual outcomes were poor despite treatment. Nine patients had Snellen acuity of 6/60 or less and required low visual aids to function. Aniridia is a disorder that requires multiple surgeries. It has a poor visual prognosis d...Continue Reading

References

Jun 1, 1992·Ophthalmic Paediatrics and Genetics·U M Mayer
Apr 11, 1992·Archives of Ophthalmology·R E Wiggins, K F Tomey
Sep 1, 1990·The British Journal of Ophthalmology·V JotterandA St-Pierre
Aug 1, 1985·Ophthalmic Paediatrics and Genetics·R Koster, A T van Balen
May 1, 1984·Survey of Ophthalmology·L B NelsonL Jackson
Jan 1, 1984·Archives of Ophthalmology·A C MoltenoG Van Biljon
Jan 1, 1995·Eye·J G DowlerR J Cooling
Sep 1, 1995·American Journal of Ophthalmology·K NishidaS Yamamoto
Oct 1, 1995·European Journal of Pediatrics·I IvanovR Weitz
Jan 27, 1998·Ophthalmology·D K WallaceF D Ellis
Oct 12, 2001·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F E Kruse, T Reinhard
Mar 29, 2003·Journal of Cataract and Refractive Surgery·Susan SchneiderRichard Montione
May 6, 2004·American Journal of Ophthalmology·Fumiki OkamotoTetsuro Oshika
Jun 3, 2004·Journal français d'ophtalmologie·M LaghmariZ Mohcine
Sep 11, 2004·Eye·T J McCulleyE J Holland
Nov 24, 2004·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Alejandra Valenzuela, Roy A Cline
Jun 5, 2007·American Journal of Ophthalmology·Esen Karamursel AkpekClaes H Dohlman
Feb 5, 2008·American Journal of Ophthalmology·Elias I TraboulsiBrian G Mohney

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Citations

Aug 6, 2011·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Kevin Gregory-EvansCheryl Y Gregory-Evans
Dec 2, 2014·Korean Journal of Ophthalmology : KJO·Ji Woong ChangYoung Suk Yu
Oct 15, 2014·The American Orthoptic Journal·Paula Schanilec, Ronald Biernacki
Jul 6, 2017·BMC Ophthalmology·Jin Da WangXiu Hua Wan
Oct 27, 2020·Japanese Journal of Ophthalmology·Jonathan Cheuk-Hung ChanJimmy Shiu-Ming Lai
Jul 31, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ramanjit SihotaAshish Upadhyay

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