Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center

Journal of Neurosurgery
Matthew S AgamGabriel Zada

Abstract

OBJECTIVEPituitary adenomas (PAs) are benign neoplasms that are frequently encountered during workup for endocrinopathy, headache, or visual loss. Transsphenoidal surgery remains the first-line approach for PA resection. The authors retrospectively assessed complication rates associated with transsphenoidal PA resection from an institutional database.METHODSA retrospective analysis of 1153 consecutive transsphenoidal pituitary adenoma resections performed at the Keck Hospital of USC between November 1992 and March 2017 was conducted. Microscopic transsphenoidal resection was performed in 85.3% of cases, and endoscopic transsphenoidal resection was performed in 14.7%. Analysis of perioperative complications and patient and tumor risk factors was conducted.RESULTSThe overall median hospital stay was 3 days. There was 1 perioperative death (0.1%). Surgical complications included postoperative cerebrospinal fluid leak (2.6%), epistaxis (1.1%), postoperative hematoma (1.1%), meningitis (1.0%), cranial nerve paresis (0.8%), hydrocephalus (0.8%), vision loss (0.6%), stroke (0.3%), abdominal hematoma or infection (0.2%), carotid artery injury (0.1%), and vegetative state (0.2%). Perioperative medical complications included bacteremia/s...Continue Reading

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Citations

Jul 28, 2019·Journal of Neurosurgery·Simona Mihaela FloreaHenry Dufour
Jun 28, 2019·European Endocrinology·Elena V VarlamovMaria Fleseriu
Jun 4, 2020·Reviews in Endocrine & Metabolic Disorders·Pietro MortiniAndrea Giustina
Jun 6, 2020·Reviews in Endocrine & Metabolic Disorders·Michael Buchfelder, Sven-Martin Schlaffer
May 7, 2021·British Journal of Neurosurgery·Philip Dao TrongChristopher Beynon
May 18, 2021·Biomedical Optics Express·Alycen Wiacek, Muyinatu A Lediju Bell
Oct 17, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·David B ClarkeSyed Ali Imran
Oct 1, 2021·Acta chirurgica Belgica·Charlotte NysDiederik Peuskens
Mar 14, 2020·Journal of Neurosurgery·Khodayar GoshtasbiEdward C Kuan

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