Complications following Nipple-Sparing Mastectomy and Immediate Acellular Dermal Matrix Implant-based Breast Reconstruction-A Systematic Review and Meta-analysis

Plastic and Reconstructive Surgery. Global Open
Lene Nyhøj HeidemannJørn Bo Thomsen

Abstract

Acellular dermal matrix was introduced in breast reconstruction in 2001 and is gradually becoming a standard component for immediate breast reconstruction and nipple-sparing mastectomy. The reconstructive technique allows for improved aesthetic outcomes. However, there seems to be uncertainty regarding complication rates. The aim of this review was to systematically evaluate complication rates related to this method. This systematic review was conducted according to the recommendations outlined in the Cochrane Handbook for reviews and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Relevant databases were searched for in the literature concerning the use of acellular dermal matrix in implant-based nipple-sparing mastectomy and immediate breast reconstruction. All studies underwent detailed quality assessment. Summarized outcome rates were computed using meta-analysis. Nine of 1,039 studies were eligible for inclusion yielding 778 procedures. The quality was acceptable for all included studies. The meta-analysis found the rate of skin necrosis to be 11%, nipple necrosis 5%, infection in 12%, hematoma in 1%, treated seroma in 5%, explantation 4%, and unplanned return to the ...Continue Reading

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Citations

Jul 12, 2018·Annals of Surgery·Robert J DabekDaniel Driscoll
Mar 22, 2019·Molecular Medicine Reports·Yan-Ling QiuXu-Qian Liu
Jul 25, 2019·Plastic and Reconstructive Surgery. Global Open·Maurice Y Nahabedian
Jun 17, 2020·Plastic and Reconstructive Surgery. Global Open·Arash MomeniIrene L Wapnir
Sep 25, 2020·Journal of Medical Case Reports·Avra S LaarakkerStephanie Fine
May 19, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A GilmourL Martin

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