Complications Following Therapeutic Bronchoscopy for Malignant Central Airway Obstruction: Results of the AQuIRE Registry

Chest
David E OstAQuIRE Bronchoscopy Registry

Abstract

There are significant variations in how therapeutic bronchoscopy for malignant airway obstruction is performed. Relatively few studies have compared how these approaches affect the incidence of complications. We used the American College of Chest Physicians (CHEST) Quality Improvement Registry, Evaluation, and Education (AQuIRE) program registry to conduct a multicenter study of patients undergoing therapeutic bronchoscopy for malignant central airway obstruction. The primary outcome was the incidence of complications. Secondary outcomes were incidence of bleeding, hypoxemia, respiratory failure, adverse events, escalation in level of care, and 30-day mortality. Fifteen centers performed 1,115 procedures on 947 patients. There were significant differences among centers in the type of anesthesia (moderate vs deep or general anesthesia, P < .001), use of rigid bronchoscopy (P < .001), type of ventilation (jet vs volume cycled, P < .001), and frequency of stent use (P < .001). The overall complication rate was 3.9%, but significant variation was found among centers (range, 0.9%-11.7%; P = .002). Risk factors for complications were urgent and emergent procedures, American Society of Anesthesiologists (ASA) score > 3, redo therapeut...Continue Reading

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Citations

Dec 15, 2015·American Journal of Respiratory and Critical Care Medicine·Jared M RadbelSabiha Hussain
Sep 16, 2015·Annals of the American Thoracic Society·David E Ost, Daniel H Sterman
Mar 8, 2016·Current Opinion in Pulmonary Medicine·Stefano Gasparini, Martina Bonifazi
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Nov 4, 2015·Chest·David E Ost
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May 5, 2018·Expert Review of Respiratory Medicine·Hitesh Batra, Lonny Yarmus
Mar 15, 2018·Current Opinion in Pulmonary Medicine·Bruce F Sabath, David E Ost
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May 31, 2019·Annals of the American Thoracic Society·Majid ShafiqDavid Feller-Kopman
Apr 9, 2020·Journal of Bronchology & Interventional Pulmonology·Bryan S BennGanesh Krishna
Nov 5, 2019·Chest·Momen M WahidiLonny Yarmus
Nov 20, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Antoni Rosell, Grigoris Stratakos
Jan 30, 2021·BMJ Open Respiratory Research·Alain TremblayChristopher Hergott
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Feb 26, 2019·Respiration; International Review of Thoracic Diseases·Labib DebianeDavid E Ost
Apr 8, 2020·Respiration; International Review of Thoracic Diseases·Van Kim HoldenAdnan Majid

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