Complications in IDDM are caused by elevated blood glucose level: the Stockholm Diabetes Intervention Study (SDIS) at 10-year follow up

Diabetologia
P ReichardJ Sule

Abstract

Blood glucose values close to normal reduce the microvascular complications of insulin-dependent diabetes mellitus. The Stockholm study of this effect continued after the initial 7.5-year period in order to see what happened when intensively treated patients were left to control their own treatment while treatment was intensified in the control group. Forty-three patients with insulin-dependent diabetes randomised to intensified conventional treatment (ICT) and 48 patients randomised to standard treatment (ST) were followed-up for 10 years. Vascular complications, treatment side-effects and well-being were studied. Risk factors for complications were sought. HbA1c (normal range 3.9-5.7%) was reduced from 9.5 +/- 1.4% (mean +/- SD) in the ICT group and 9.4 +/- 1.2% in the ST group to a mean (during 10 years) of 7.2 +/- 0.6% and 8.3 +/- 1.0%, respectively (p < 0.001). Serious retinopathy (63 vs 33%, p = 0.003), nephropathy (26 vs 7%, p = 0.012) and symptoms of neuropathy (32 vs 14%, p = 0.041) were more common in the ST group after 10 years. HbA1c and age were the only risk factors for complications. Self-reported well-being increased to a greater degree and severe hypoglycaemia was more common in the ICT group. Cognitive functio...Continue Reading

Citations

Apr 11, 2000·The Journal of Maternal-fetal Medicine·G Leguizamon, E A Reece
Mar 20, 2003·Current Diabetes Reports·A Adler
Nov 23, 2006·Current Diabetes Reports·Dinesh Selvarajah, Solomon Tesfaye
May 1, 2008·Current Diabetes Reports·Gail Musen
Jun 8, 2001·Clinical Therapeutics·J E Gerich
Oct 12, 2000·Diabetes Research and Clinical Practice·L C Lantion-Ang
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·D J Becker, C M Ryan
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·Y GroeneveldM P Springer
May 6, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·R Stewart, D Liolitsa
Feb 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·P ReichardL E Lindblad
May 23, 2009·Diabetes Technology & Therapeutics·Anthony L McCallBoris Kovatchev
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kin Hung LiuJuliana Chung Ngor Chan
Nov 11, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ece BöberFrancesco Chiarelli
Mar 3, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria NordwallJohnny Ludvigsson
Dec 20, 2012·Wiener klinische Wochenschrift·Monika LechleitnerMario Francesconi
Sep 21, 2002·Current Medical Research and Opinion·W NitiyanantJ P Yeo
Jun 1, 2012·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Philip HooperDavid A L Maberley
Jan 1, 2003·Journal of the American Pharmaceutical Association : APhA·Victoria J Babb, John Babb
Jul 2, 2015·Annals of the New York Academy of Sciences·Amir MoheetElizabeth R Seaquist
Dec 6, 2003·Pediatric Diabetes·Timothy W Jones, Elizabeth A Davis
Dec 8, 2006·Annals of the New York Academy of Sciences·Anders A F Sima, Hideki Kamiya
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A R ChacraUNKNOWN COMPLETE T1D investigators
Sep 1, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·B RathsmanT Nyström
Apr 20, 2004·European Journal of Pharmacology·Augustina M A BrandsGeert Jan Biessels
May 23, 2015·BioMed Research International·Mervi E HyvönenSanna Lehtonen
Apr 22, 2016·Implementation Science : IS·Andrea C TriccoSharon E Straus
Dec 28, 2002·Diabetes·Stewart C FergusonBrian M Frier
Mar 1, 2005·Diabetes Care·Augustina M A BrandsRoy P C Kessels
Mar 29, 2003·Diabetes Care·Soffia GudbjörnsdottirUNKNOWN Steering Committee of the Swedish National Diabetes Register
Dec 10, 2013·Diabetes Care·Naama Barnea-GoralyUNKNOWN Diabetes Research in Children Network (DirecNet)
Oct 10, 2013·Diabetes Care·Insa FeinkohlUNKNOWN Edinburgh Type 2 Diabetes Study (ET2DS) Investigators

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.