Complications in pediatric intestine transplantation in the absence of peri-operative donor or recipient bowel decontamination

Pediatric Transplantation
Jared W ClouseRichard S Mangus

Abstract

This study reports the clinical complication and infection rates of an active pediatric IT program that has never utilized bowel decontamination in either the donor or the recipient. All patients undergoing IT from 2003 to 2015 at a single pediatric IT center were reviewed. Post-transplant surgical, infectious, and immunosuppressive complications are reported. There were 52 patients who underwent IT during the study period. Among these patients, 4% developed a postoperative abscess, one developed an enteric fistula (2%), and one had an enteric or anastomotic leak (2%). The rate of any bacterial infection was 90% in the first year, with a wound infection rate of 23%. Any fungal infection occurred in 25% of patients. Any viral infection occurred in 75% of patients. Gastrointestinal viruses were diagnosed in 52% of patients, and cytomegalovirus infections occurred in 17%. Rejection rates were 39% at any time post-transplant (isolated 44% and 35% for multivisceral patients). At this center in which no bowel decontamination was used, rates of surgical complications, infections, and rejection were similar to those reported by other centers. These findings suggest bowel decontamination may provide no significant benefit in this popula...Continue Reading

References

Sep 10, 2003·Transplantation Proceedings·C LoinazA Tzakis
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G SelvaggiA G Tzakis
Jul 16, 2008·Transplantation·Rodrigo ViannaA Joseph Tector
May 23, 2009·Transplantation Proceedings·A CucchettiA D Pinna
Jul 16, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D F FlorescuA C Kalil
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K AkhterP Kumar
Dec 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P L OhD F Mercer
Mar 14, 2012·Nature Reviews. Genetics·Ilseung Cho, Martin J Blaser
Apr 3, 2012·The Pediatric Infectious Disease Journal·Diana F FlorescuAndre C Kalil
May 3, 2012·Annals of Surgery·Rodrigo M ViannaA Joseph Tector
Nov 13, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J T SilvaJ Maria Aguado

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Citations

May 11, 2018·The Pediatric Infectious Disease Journal·Jared W ClouseRichard S Mangus
Jan 3, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·José R Bretón-MartínezCecilia Martínez-Costa

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