Abstract
Similar to adults, CKD may persist after pediatric RTx. Clinical and laboratory parameters were analyzed retrospectively in 23 RTx recipients (13 males, age 11.9 +/- 5.2 yr), initially treated with prednisone, calcineurin inhibitor (TAC = 18, cyclosporine neoral = 5), and MMF at four months post-RTx (T1) and at 3.4 +/- 2.8 yr post-RTx (T2). Mean (+/-s.d.) cystatin C GFR (mL/min/1.73 m(2)) was 72 +/- 19 at T1 and 70 +/- 22 at T2 (NS). At T2, CKD stage I was present in five patients (22%), stage II in eight patients (35%), and stage III in 10 patients (43%). At T2, calcineurin inhibitors were utilized in 19, MMF in 13, and SIR in 13 patients. The prevalence of hypertension was 69% at T1 and 87% at T2 (p = NS). Anemia was diagnosed in 61% at T1 and 69% at T2 with average therapeutic MMF (2.78 +/- 1.3 mg/mL) and SIR (7.62 +/- 2.3 mg/mL) trough levels. Hypercholesterolemia was detected in 44.0% at T1 and 47% at T2. Bone disease was diagnosed in 26.0% at T1 and 21.7% at T2. Mean height Z-scores were -1.0 +/- 1.2 (T1) and -1.0 +/- 1.59 (T2, NS), with 21% at T1 and 30% at T2 below two SDS. We observed suboptimal growth, hypertension, hypercholesterolemia, bone disease, and anemia in a significant proportion of transplanted children.
References
Oct 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·H J BaluarteA Tejani
Jun 5, 2003·Pediatrics·Ronald J HoggUNKNOWN National Kidney Foundation's Kidney Disease Outcomes Quality Initiative
Aug 16, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guido Filler, Nathalie Lepage
Oct 9, 2003·Kidney International·Arjang DjamaliBryan N Becker
Feb 21, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Vanji KarthikeyanGreg Knoll
Jul 16, 2004·Kidney International·Elke WühlUNKNOWN ESCAPE Trial Group
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
Sep 9, 2004·Hypertension·Bonita Falkner, Stephen R Daniels
May 11, 2005·Kidney International·Guido FillerJochen H H Ehrich
Oct 21, 2005·Journal of the American Society of Nephrology : JASN·Christine WhiteGreg A Knoll
Apr 28, 2006·Transplantation·Nilesh ShahDavid J A Goldsmith
May 9, 2006·Pediatric Transplantation·Amr A El-HusseiniMohamed A Sobh
May 9, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN KDOQI, UNKNOWN National Kidney Foundation
Jun 8, 2006·Transplantation Proceedings·E BertoniM Salvadori
Jun 22, 2006·Kidney International·H WongG Filler
Nov 14, 2006·Transplantation Proceedings·G Fernandez-FresnedoM Arias
Dec 1, 2006·Nephron. Clinical Practice·Lesley ReesRichard S Trompeter
Citations
Jan 20, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justine BacchettaPierre Cochat
Nov 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rajiv SinhaStephen D Marks
Apr 11, 2014·Nephro-urology Monthly·Guido Filler
Jan 9, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisa C YooGuido Filler
Sep 20, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Leah A KrischockUNKNOWN ESPN/ERA-EDTA Registry
Jul 22, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Amy C Wilson, Mark M Mitsnefes
Dec 11, 2008·Pediatric Transplantation·Guido Filler, Ajay P Sharma
Jun 15, 2012·Pediatric Transplantation·Arianna DégiGeorge S Reusz
Feb 16, 2012·Pediatric Transplantation·Guido Filler, Shih-Han Susan Huang
Sep 3, 2011·Pediatric Transplantation·Anne TsampalierosJanusz Feber
Nov 30, 2011·Pediatric Transplantation·Guido FillerJoanne Grimmer
Dec 16, 2010·Pediatric Transplantation·Guido Filler
Dec 4, 2012·Pediatric Transplantation·Guido Filler, Shih-Han Susan Huang
Oct 19, 2013·Pediatric Transplantation·Maital KaidarMiriam Davidovits
Feb 27, 2016·Pediatric Transplantation·Guido FillerStephen D Marks
May 1, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tomáš RosíkTomáš Seeman
Apr 29, 2016·Pediatric Transplantation·George ReuszEva Kis
Feb 15, 2018·Pediatric Transplantation·Jonathan N Johnson, Guido Filler
Nov 3, 2009·Paediatric Drugs·Britta Höcker, Burkhard Tönshoff
May 1, 2010·Therapeutic Drug Monitoring·Guido Filler, Shih-Han S Huang
Aug 17, 2020·Pediatric Transplantation·Çiğdem OruçFatma Lale Sever