Complications of cirrhosis

Current Opinion in Gastroenterology
Robert S Rahimi, Don C Rockey

Abstract

Chronic liver disease (CLD) causes significant morbidity and mortality, mainly due to complications [hepatic encephalopathy, ascites, hepatorenal syndrome (HRS), and esophageal variceal hemorrhage (EVH)]. Studies of the complications, management and outcomes in patients with CLD over the past 18 months are reviewed. Percutaneous liver biopsy can be safely performed in patients with advanced liver disease with minimal complications. Predictors of response to lactulose, probiotics and L-ornithine-L-aspartate therapy in minimal hepatic encephalopathy have been reported. Rifaximin was found to lead to better maintenance of remission and decreased re-admission rates in patients with cirrhosis and hepatic encephalopathy, and may improve driving performance in those with minimal hepatic encephalopathy. In a controversial study, patients with refractory ascites taking propranolol were found to have poorer outcomes, perhaps related to beta-blockade associated paracentesis-induced circulatory dysfunction. Terlipressin and albumin therapy currently appears to be the best medical therapy available in patients with type 1 HRS, although pentoxifylline may be effective to treat HRS in patients with cirrhosis and ascites. In patients with gast...Continue Reading

References

Nov 14, 2007·Gut·R Spiller
Mar 5, 2010·The New England Journal of Medicine·Guadalupe Garcia-Tsao, Jaime Bosch
Mar 26, 2010·The New England Journal of Medicine·Nathan M BassWilliam P Forbes
Apr 7, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Leonard B SeeffUNKNOWN HALT–C Trial Group
Jun 29, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas SerstéDidier Lebrec
Sep 4, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sumeet K AsraniW Ray Kim
Oct 19, 2010·Gastroenterology Clinics of North America·Cecilia Miñano, Guadalupe Garcia-Tsao
Jun 8, 2011·European Journal of Gastroenterology & Hepatology·Vibhu Vibhas MittalShiv Kumar Sarin

❮ Previous
Next ❯

Citations

Feb 7, 2013·Current Opinion in Critical Care·Peter Faybik, Claus-Georg Krenn
Aug 1, 2013·World Journal of Gastroenterology : WJG·Camila MarquesNorma Possa Marroni
Jun 12, 2013·Journal of the Chinese Medical Association : JCMA·Yun-Hsuan LeeTeh-Ia Huo
Jun 23, 2015·Pediatrics International : Official Journal of the Japan Pediatric Society·Qianfu LuoChunbao Guo
Jul 19, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sumeet K AsraniPatrick S Kamath
Nov 20, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Manish Kumar LuniaSiddharth Srivastava
Oct 17, 2013·Journal of Hepatology·Juan CordobaUNKNOWN CANONIC Study Investigators of EASL-CLIF Consortium
May 16, 2015·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Chaitanya PantRichard Gilroy
Dec 11, 2014·PloS One·Jarrett E K ByrnesZen Faulkes
Mar 14, 2013·Seminars in Cardiothoracic and Vascular Anesthesia·Timothy H Hall, Achal Dhir
Jun 27, 2017·Oral Diseases·M A FigueiredoK L Ortega
Feb 24, 2017·The Cochrane Database of Systematic Reviews·Rohan DalalAngela C Webster
Nov 18, 2014·World Journal of Gastroenterology : WJG·Isabel Gómez-HurtadoRubén Francés
Sep 10, 2014·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Krishna C SajjaDon C Rockey
Sep 23, 2016·Canadian Journal of Gastroenterology & Hepatology·Becky ChenOrlee R Guttman
Aug 2, 2017·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·K JananiVenkataraman Jayanthi
Mar 1, 2015·Digestive Diseases and Sciences·Chanda K HoRalph Gonzales
Jun 26, 2015·World Journal of Gastroenterology : WJG·De-Run KongJian-Ming Xu
May 4, 2016·The American Journal of the Medical Sciences·Robert S Rahimi, Don C Rockey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Gastroenterology
Robert S Rahimi, Don C Rockey
European Journal of Radiology
Giuseppe BrancatelliValérie Vilgrain
Seminars in Respiratory and Critical Care Medicine
Juan Carlos García-PagánJaime Bosch
© 2022 Meta ULC. All rights reserved