Complications of herpes zoster in immunocompetent older adults: Incidence in vaccine and placebo groups in two large phase 3 trials

Vaccine
Martina KovacZOE-50/70 Study Group

Abstract

An adjuvanted herpes zoster (HZ) subunit vaccine, HZ/su, demonstrated high efficacy against HZ and postherpetic neuralgia (PHN) in two randomized, observer-blind, placebo-controlled trials in adults aged ≥50 and ≥70 years (ZOE-50 and ZOE-70, respectively). Data from ZOE-50 and ZOE-70 trials were analyzed to evaluate the efficacy of HZ/su against mortality, hospitalizations, and non-PHN complications of HZ including HZ-associated vasculitis, stroke, and disseminated, ophthalmic, neurologic, and visceral diseases. In the pooled ZOE-50/ZOE-70 analysis, 1 of 32 HZ/su recipients (3.1%) and 16 of 477 placebo recipients (3.4%) with a confirmed HZ episode had complications other than PHN. Efficacy against HZ-related complications was 93.7% (95% confidence interval, 59.5-99.9%) in adults aged ≥50 years and 91.6% (43.3-99.8%) in adults ≥70 years. Five HZ-related hospitalizations, all in placebo recipients, and no HZ-related deaths were reported. HZ/su reduces the risk of HZ-associated complications in older adults (NCT01165177; NCT01165229).

Citations

Mar 28, 2019·Current Medical Research and Opinion·Helen SenderovichMaheen Mujtaba
Nov 8, 2019·The Cochrane Database of Systematic Reviews·Anna Mz GagliardiEduardo Canteiro Cruz
Dec 13, 2019·The Journal of Infectious Diseases·Rafael Harpaz
Nov 22, 2018·PloS One·Harriet J ForbesCharlotte Warren-Gash
Feb 6, 2020·Open Forum Infectious Diseases·Fawziah MarraNirma Vadlamudi
Feb 24, 2021·BMJ : British Medical Journal·Anthony L CunninghamMyron J Levin
Oct 21, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lucas GuilloLaurent Peyrin-Biroulet
Aug 8, 2019·Actas dermo-sifiliográficas·D Morgado-CarrascoP Giavedoni

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