Complications of pancreaticoduodenectomy after neoadjuvant chemoradiation in patients with and without preoperative biliary drainage

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
H GerkeJ Baillie

Abstract

It has been suggested that preoperative biliary drainage increases the risk of infectious complications of pancreaticoduodenectomy. The aim of this study was to assess complications related to biliary stents/drains and postoperative morbidity in patients undergoing neoadjuvant chemoradiotherapy for periampullary cancer. One hundred and eighty-four patients with periampullary neoplasms were prospectively selected for neoadjuvant external beam radiation therapy and 5-fluorouracil-based chemotherapy between 1995 and 2002. The data were retrospectively completed and analysed with respect to biliary drainage, efficacy and complications of endoscopic biliary stents and postoperative morbidity. Patients who had undergone a surgical biliary bypass were excluded. Data were completed in 168 patients. One hundred and nineteen patients were treated with endoscopic biliary stents, 18 patients had a percutaneous biliary drain and 31 patients did not require biliary drainage. Hospitalisation for stent-related complications was necessary in 15% of the patients with endoscopic biliary stents. Seventy-two patients underwent pancreaticoduodenectomy. There was no significant difference in the rate of wound infections, intra-abdominal abscesses and...Continue Reading

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Citations

Feb 24, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L CipollettaUNKNOWN Italian Evidence-Based Gastroenterology & Hepatology Club
Sep 28, 2010·Journal of Surgical Oncology·Vedra A AugensteinRobert C G Martin
Sep 8, 2004·Surgical Oncology Clinics of North America·Rebekah R White, Douglas S Tyler
Jan 27, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C H CraneR A Wolff
Mar 14, 2009·Current Gastroenterology Reports·Alan Coss, Michael F Byrne
Dec 22, 2017·Annals of Hepato-biliary-pancreatic Surgery·Zi Qin NgSudhakar Rao
Jan 13, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·I DimitriouM Niedergethmann

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