Complications of type 1 diabetes: new molecular findings

The Mount Sinai Journal of Medicine, New York
Alin StirbanDiethelm Tschoepe

Abstract

Interventions targeting the treatment of diabetic complications have not been nearly as successful as initially estimated, despite a marked improvement in therapeutic options for diabetes. The need for understanding why some very promising interventions have failed demands a closer look at the pathomechanisms of the complications. Great strides have been made in understanding the pathology, and several important hypotheses have emerged in recent years. On this basis, Brownlee and coworkers suggested a unifying hypothesis integrating various mechanisms discussed in past years with an overproduction of reactive oxygen species as an initiating cause. This hypothesis and further hypotheses, as well as mechanisms, are highlighted in this article. The field of pathomechanisms of diabetic complications is very wide, and any attempt to completely cover it within a single article is unrealistic. Therefore, our purpose is to present the most relevant concepts underlying diabetic complications in an attempt to contribute to a better understanding and pinpoint areas that warrant further research.

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Citations

Jun 8, 2011·Clinical & Developmental Immunology·Meghan M Delmastro, Jon D Piganelli
Jul 27, 2010·Journal of Immunological Methods·Michael W Jackson, Tom P Gordon
Aug 21, 2010·Molecular Nutrition & Food Research·Martinus van BoekelGerhard Eisenbrand
May 24, 2017·Expert Opinion on Biological Therapy·Jennifer AdeghateErnest Adeghate

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