Component-resolved diagnostics in vernal conjunctivitis

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Alicia ArmentiaJesus Bermejo

Abstract

Conventional diagnostic tests in allergy are insufficient to clarify the origin of vernal conjunctivitis (VC). To evaluate IgE-mediated hypersensitivity by component-resolved diagnosis (CRD) in tears and serum from patients with VC and to evaluate how to treat patients with identified triggering allergens by specific immunotherapy. Patients were divided into 3 groups: (1) patients with VC (25 patients), (2) patients allergic to grass pollen with seasonal allergic conjunctivitis (AC) (50 patients), and (3) healthy blood donors (50 patients). If triggering allergens were detected, specific conventional immunotherapy was administered for 1 year. Twenty-five patients with VC were evaluated. The identified triggering allergens were n Lol p 1 (11 patients), n Cyn d 1 (8 patients), group 4 and 6 grasses (6 patients), and group 5 grasses (5 patients). Prick test and pollen IgE test results were positive in one patient. Clinical improvement was observed in 13 of the 25 patients with VC after 1 year of specific immunotherapy. CRD seems to be a more sensitive diagnostic tool compared with prick test and IgE detection. Specific CRD-led immunotherapy may achieve clinical improvements in patients with VC.

References

Mar 20, 2001·Archives of Ophthalmology·K F Tabbara
Feb 13, 2003·Current Opinion in Allergy and Clinical Immunology·Leonard Bielory, Anu Mongia
Apr 20, 2004·Drugs of Today·J Joss, T Craig
Sep 7, 2006·Current Opinion in Allergy and Clinical Immunology·Beth Lillian Schultz
Aug 21, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose Manuel González-BuitragoIgnacio Dávila
Jun 19, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Salcedo, A Diaz-Perales
Mar 8, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J-M GrouinP Devillier
Aug 9, 2011·Current Opinion in Allergy and Clinical Immunology·Mitchell H Friedlaender
Dec 20, 2011·Ophthalmology·Andrea LeonardiIva Fregona
Oct 9, 2012·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization Collaborating Center for Asthma and Rhinitis
Mar 19, 2013·Italian Journal of Pediatrics·Mario La RosaAlfredo Reibaldi
Aug 27, 2013·Current Opinion in Allergy and Clinical Immunology·Andrea Leonardi, Stefano Bonini
Oct 18, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Athira RohitMark D P Willcox

❮ Previous
Next ❯

Citations

Dec 29, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Gailen D MarshallLeonard Bielory
Mar 18, 2020·The World Allergy Organization Journal·UNKNOWN Steering Committee Authors, UNKNOWN Review Panel Members

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.