Components of diesel exhaust particles diversely enhance a variety of respiratory diseases related to infection or allergy: extracted organic chemicals and the residual particles after extraction differently affect respiratory diseases

Journal of Clinical Biochemistry and Nutrition
Hirohisa TakanoKen-Ichiro Inoue

Abstract

Experimental and epidemiological studies have reported that diesel exhaust particles (DEP) can aggravate a variety of respiratory diseases including infection or allergy. However, the responsible components in DEP for the enhancement have not been identified. The present review demonstrates the different effects of the components of DEP on the respiratory diseases related to infection or allergy. We exposed mice to the organic chemicals (DEP-OC) and the residual carbonaceous nuclei (washed DEP) derived from DEP in the presence or absence of bacterial endotoxin (lipopolysaccharide: LPS) or allergen. In our first series of experiments, washed DEP combined with LPS synergistically exacerbated lung injury, which was concomitant with the enhanced lung expression of proinflammatory cytokines and chemokines, whereas DEP-OC combined with LPS did not. In contrast, our second series of experiments showed that DEP-OC, rather than washed DEP, enhanced allergen-related eosinophilic inflammation and proliferation of goblet cells in the airway epithelium, which was paralleled by the enhanced lung expression of eotaxin and interleukin-5. However, washed DEP with ovalbmin showed less change and increased the lung expression of interferon-gamma....Continue Reading

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Citations

Jan 30, 2009·Journal of Clinical Biochemistry and Nutrition·Yasuhiro KambayashiHiroyuki Nakamura
Mar 20, 2013·BioMed Research International·P E SchwarzeJ Øvrevik
Nov 22, 2011·Toxicology Letters·Annike Irene TotlandsdalMarit Låg
Dec 19, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Annike I TotlandsdalAlena Kubátová
Dec 22, 2016·Basic & Clinical Pharmacology & Toxicology·Johan ØvrevikJørn A Holme
Mar 29, 2013·The Journal of Toxicological Sciences·Takayuki KumamotoShigeru Oshio
Mar 13, 2009·Critical Reviews in Toxicology·Thomas W HesterbergPeter A Valberg

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