PMID: 8596695Feb 1, 1996Paper

Components of energy expenditure in the mdx mouse model of Duchenne muscular dystrophy

Pflügers Archiv : European journal of physiology
A MokhtarianP C Even

Abstract

Previous observations showing that basal heat production rates and glucose metabolism were reduced in mdx mouse skeletal muscles incubated in vitro led us to study the components of total energy expenditure by open-circuit indirect calorimetry in the intact, free-moving mdx mouse. Our purpose was to verify if the mdx mouse exhibited whole-body alterations in energy metabolism. The results revealed that total and basal energy expenditure, as well as spontaneous activity, energetic cost of activity, and, therefore, energy expended in relation to activity were not significantly different in C57B1/10 (control) and in dystrophic (mdx) mice. In contrast, the thermic effect of food was 32% larger in mdx than in control mice and was accompanied by significant differences in post-prandial glucose and lipid oxidation. The present in vivo study could not show a direct demonstration that impaired glucose metabolism by skeletal muscles participated in this phenomenon. However, since post-prandial glucose metabolism by skeletal muscles contributes a significant part of the thermic effect of food, the present data are in line with previous studies in vitro that show that mdx mouse skeletal muscles probably suffer an impaired control of their ...Continue Reading

References

May 1, 1978·The American Journal of Clinical Nutrition·I Krieger
Dec 1, 1988·Journal of Muscle Research and Cell Motility·J E AndersonW K Ovalle
Oct 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·M J Dauncey, D Brown
Aug 1, 1987·Journal of the Neurological Sciences·J W Carnwath, D M Shotton
Mar 1, 1985·The Journal of Nutrition·J Hoover-Plow, B Nelson
Jan 1, 1967·Acta Neurologica Scandinavica·V IonăşescuO Vuia
Nov 1, 1984·Muscle & Nerve·J Dangain, G Vrbova
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G BulfieldK J Moore
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·P C EvenA Pele
Dec 1, 1994·The Biochemical Journal·P C EvenA Chinet
Feb 1, 1994·Journal of the Neurological Sciences·E E Dupont-VersteegdenM G Vonlanthen
Sep 1, 1993·The British Journal of Nutrition·P C Even, S Nicolaïdis
Dec 1, 1993·Journal of the Neurological Sciences·F MuntoniG Serra
Jun 1, 1993·Journal of the Neurological Sciences·G J KempG K Radda
Jun 1, 1959·The Journal of Clinical Investigation·P J VIGNOS, M LEFKOWITZ
Oct 1, 1947·Physiological Reviews·M KLEIBER

❮ Previous
Next ❯

Citations

Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Julian L Griffin
Nov 19, 2011·PLoS Currents·Hannah G Radley-CrabbMiranda D Grounds
Nov 24, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B PalmieriA Pietrobelli
Jul 31, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J L GriffinJ K Nicholson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the Neurological Sciences
E E Dupont-VersteegdenM G Vonlanthen
European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
Sarah A ElliottH Truby
© 2021 Meta ULC. All rights reserved