Components of the basal lamina and dystrophin-dystroglycan complex in the neurointermediate lobe of rat pituitary gland: different localizations of beta-dystroglycan, dystrobrevins, alpha1-syntrophin, and aquaporin-4

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Károly PócsaiMihaly Kalman

Abstract

The so-called neurointermediate lobe is composed of the intermediate and neural lobes of the pituitary. The present immunohistochemical study investigated components of the basal lamina (laminin, agrin, and perlecan), the dystrophin-dystroglycan complex (dystrophin, beta-dystroglycan, alpha1-dystrobrevin, beta-dystrobrevin, utrophin, and alpha1-syntrophin), and the aquaporins (aquaporin-4 and -9). Glia markers (GFAP, S100, and glutamine synthetase) and components of connective tissue (collagen type I and fibronectin) were also labeled. In the neurohypophysis, immunostaining of basal lamina delineated meningeal invaginations. In these invaginations, vessels were seen to penetrate the organ without submerging into its parenchyma. On the parenchymal side of the invaginations, beta-dystroglycan was detected, whereas utrophin was detected in the walls of vessels. Immunostaining of alpha1-dystrobrevin and alpha1-syntrophin did not delineate the vessels. The cells of the intermediate lobe were fully immunoreactive to alpha1-dystrobrevin and alpha1-syntrophin, whereas components of the basal lamina delineated the contours of the cells. GFAP-immunoreactive processes surrounded them. Aquaporin-4 localized at the periphery of the neurohyp...Continue Reading

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Citations

Feb 23, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ouahiba Mesbah-BenmessaoudValérie Grange-Messent
Feb 13, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Károly Pócsai, Mihaly Kalman

Methods Mentioned

BETA
electron microscopy
Scanning Microscopy

Related Concepts

SNTA1 protein, human
Dystrobrevin
Aqp4 protein, rat
Axon
Basement Membrane
Calcium-Binding Proteins
Glial Fibrillary Acidic Protein
Merosin
Cell Surface Proteins
Muscle Proteins

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