Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids

Diabetologia
P RumpG Hornstra

Abstract

According to the foetal origins hypothesis, there is a relation between foetal nutrition and adult glucose intolerance. In adults, insulin resistance has been associated with dietary polyunsaturated fatty acids. We examined whether the availability of polyunsaturated fatty acids during foetal life, as indicated by the fatty acid composition of cord blood samples, relates to childhood body composition and glycaemic control. Fatty acid concentrations in umbilical cord blood were determined by gas-liquid chromatography in a birth-cohort of infants. When the children were seven years old, fasting glucose, insulin, proinsulin, and leptin levels were measured in 259 of these children, and relations with cord plasma fatty acid concentrations were studied. Cord plasma phospholipid gamma-linolenic acid and dihomo- gamma-linolenic acid concentrations were negatively related to insulin concentrations and calculated insulin resistance (homeostasis model assessment) at seven years of age. The gamma-linolenic acid concentrations were also negatively related to body fatness and proinsulin and leptin concentrations at seven years of age. No association was found for other polyunsaturated fatty acid concentrations at birth. Adjusted for age, se...Continue Reading

Citations

Oct 25, 2002·Diabetes/metabolism Research and Reviews
Jan 29, 2009·The British Journal of Nutrition·Chantal E H DirixGerard Hornstra
Aug 18, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·F RuttersM S Westerterp-Plantenga
Jan 11, 2007·Clinical Medicine & Research·Delia-Marina AlexeEleni Th Petridou
Mar 3, 2006·Expert Review of Cardiovascular Therapy·Paramjit S Tappia, Cindy A Gabriel
Jun 8, 2007·Physiology & Behavior·N VogelsM S Westerterp-Plantenga
Jan 12, 2007·Journal of Science and Medicine in Sport·Jantine D SlingerHarm Kuipers
Jun 28, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sylvia H J JochemsMaurice P Zeegers
May 30, 2015·Diabetes Research and Clinical Practice·Olaf UhlBerthold Koletzko
Apr 18, 2015·Journal of Pediatric Gastroenterology and Nutrition·Bernadette DelplanqueBirgitta Strandvik
Dec 17, 2014·The Proceedings of the Nutrition Society·Aoibheann M McMorrowHelen M Roche
Aug 30, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C HellmuthS Entringer
Aug 28, 2010·The Journal of Pediatrics·Caroline JacquesDave Saint-Amour
Apr 1, 2009·European Journal of Endocrinology·F RuttersM S Westerterp-Plantenga
Oct 7, 2006·The American Journal of Clinical Nutrition·Neeltje VogelsMargriet S Westerterp-Plantenga

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