Composite adenocarcinoma and large cell neuroendocrine carcinoma of the rectum

Virchows Archiv : an International Journal of Pathology
A MakinoR Chetty

Abstract

Composite glandular-endocrine tumors of the gastrointestinal tract are rare neoplasms. Even more uncommon are the so-called amphicrine tumors, lesions in which dual epithelial and endocrine differentiation occurs in the same cell. We describe a patient who complained of rectal pain and bleeding with a mixed or composite adenocarcinoma and neuroendocrine carcinoma of the rectum. Histological examination revealed a distinct adenocarcinoma of conventional type with glandular structures admixed intimately with a neuroendocrine carcinoma. The latter component was deeply infiltrative, while the adenocarcinoma occupied the more superficial aspect of the tumor. What was interesting was the immunophenotype of the lesion: cytokeratin (CK) 20 expression was very focal in the adenocarcinoma component and negative in the neuroendocrine carcinoma, while CK 7 was expressed strongly in the adenocarcinoma and only focally in the neuroendocrine component. This cytokeratin profile suggests a possible origin from the anal transitional zone.

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Citations

Apr 27, 2011·Journal of Gastrointestinal Cancer·Jasim RadhiLeyo Ruo
Nov 28, 2009·Nature Reviews. Clinical Oncology·Britta Weigelt, Jorge S Reis-Filho
Apr 29, 2009·Nature Reviews. Nephrology·Cataldo AbaterussoGiovanni Gambaro
Feb 2, 2010·Gastroenterology·Hung-Hua LiangPo-Li Wei
Mar 23, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Yumi MochizukiAkira Yamaguchi
Jul 5, 2016·Case Reports in Gastrointestinal Medicine·Sali Priyanka AkhileshWagle Prasad Kashinath
Apr 30, 2013·Case Reports in Gastroenterology·Yoshifumi NakayamaKoji Yamaguchi
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Aug 25, 2020·The Journal of International Medical Research·Xu LiGuoyue Lv
Feb 27, 2015·World Journal of Gastroenterology : WJG·Zhen HuangJian Ao
Aug 11, 2011·Journal of the Korean Society of Coloproctology·Yo Na KimKyung Ryoul Kim
Nov 2, 2012·European Journal of Gastroenterology & Hepatology·Raymond KarkoucheJean-François Emile
Jul 24, 2021·Clinical Case Reports·Zoi TsakirakiIoannis G Panayiotides

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