Composite cutaneous lymphoma of diffuse large B-cell lymphoma leg-type and subcutaneous panniculitis-like T-cell lymphoma

Journal of Cutaneous Pathology
Vanessa SzablewskiJean-Marie Joujoux

Abstract

Composite lymphoma (CL) is a rare disease defined by the occurrence of 2 distinct lymphomas within a single tissue at the same time. We present the case of an 89-year-old male with a clinical history of immunoglobulin M monoclonal gammapathy of undetermined significance (IgM MGUS). The patient presented cutaneous eruption of nodules on the right bottom and arm. An excisional biopsy revealed cutaneous infiltration composed of 2 components. The first one consisted of large B-cell with CD20+/MUM1+/BCL2+ phenotype whereas the second one involved the subcutaneous fat in a panniculitis manner, was CD3+/CD8+/GranzymeB+/TCRβF1+. The final diagnosis was CL of primary cutaneous large B-cell lymphoma-leg type (PCLBCL-leg type) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL). We report and characterize for the first time coexistent PCLBCL-leg type and SPTCL in a patient. This article is protected by copyright. All rights reserved.

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Citations

May 5, 2020·Bioinformatics·Di RanLingling An
Apr 12, 2019·The American Journal of Dermatopathology·Aadil AhmedKamran Mirza

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