Composite elastomeric polyurethane scaffolds incorporating small intestinal submucosa for soft tissue engineering

Acta Biomaterialia
Lincui DaHuiqi Xie

Abstract

Although soft tissue replacement has been clinically successful in many cases, the corresponding procedure has many limitations including the lack of resilience and mechanical integrity, significant donor-site morbidity, volume loss with time, and fibrous capsular contracture. These disadvantages can be alleviated by utilizing bio-absorbable scaffolds with high resilience and large strain, which are capable of stimulating natural tissue regeneration. Hence, the chemically crosslinked tridimensional scaffolds obtained by incorporating water-based polyurethane (PU) (which was synthesized from polytetramethylene ether glycol, isophorone diisocyanate, and 2,2-bis(hydroxymethyl) butyric acid) into a bioactive extracellular matrix consisting of small intestinal submucosa (SIS) have been tested in this study to develop a new approach for soft tissue engineering. After characterizing the structure and properties of the produced PU/SIS composites, the strength, Young's modulus, and resilience of wet PU/SIS samples were compared with those of crosslinked PU. In addition, the fabricated specimens were investigated using human umbilical vein endothelial cells to evaluate their ability to enhance cell attachment and proliferation. As a resu...Continue Reading

Citations

Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangxiu CaoXiaoming Li
Aug 15, 2020·Regenerative Biomaterials·Pan ZhaoJun Fan
Oct 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jie LiaoXiaoming Li
Jan 1, 2020·Progress in Biomedical Engineering·Guang YangJohn P Fisher

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