Composite endpoints: What were the odds of that?

Medical Hypotheses
Michael Poullis

Abstract

Composite endpoints are frequently utilised in clinical studies. The creation of composite endpoints in their current form, a death carries the same weight as for example a stroke, repeat revascularisation or myocardial infarction. We hypothesise that the non-death terms of a composite score should be created such that the factor involved is weighted via odds ratios for its risk of association with death. We explore and demonstrate this using previously published odds ratios for these factors, and apply it to a hypothetical trial similar to Excel, to demonstrate the principle. The same principle could be applied to composite survival endpoints, when the factors are weighted via hazard ratios.

References

Apr 24, 2012·Interactive Cardiovascular and Thoracic Surgery·Udo Abah, Stephen Large
Jul 17, 2012·The Annals of Thoracic Surgery·Betty C TongPeter K Smith
Jan 2, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Richard WarwickMichael Poullis
Feb 14, 2015·Circulation·Alexander KulikUNKNOWN American Heart Association Council on Cardiovascular Surgery and Anesthesia
Aug 19, 2015·Journal of the American Heart Association·Michael GoldfarbJonathan Afilalo
Jun 11, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Emilie P Belley-CoteRichard P Whitlock
Sep 29, 2019·The New England Journal of Medicine·Gregg W StoneUNKNOWN EXCEL Trial Investigators

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Citations

Aug 25, 2020·Environmental & Resource Economics·Samson Mukanjari, Thomas Sterner

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