Composite fiber structures with antiproliferative agents exhibit advantageous drug delivery and cell growth inhibition in vitro

Journal of Pharmaceutical Sciences
Amir KraitzerM Zilberman

Abstract

Composite core/shell fiber structures loaded with the antiproliferative drugs paclitaxel or farnesylthiosalicylate (FTS) were developed and studied. The latter is a specific nontoxic Ras inhibitor with a mild hydrophobic nature, which can also be used for local cancer treatment and stent applications. The fibers were composed of a dense polyglyconate core and a porous drug-loaded poly(D,L-lactic-glycolic acid) shell, prepared using freeze drying of inverted emulsions. Our study focused on the release profile of the antiproliferative drugs from the fibers, the shell morphology and its degradation and erosion. The postfabrication antiproliferative effect of the drugs was tested in a cell culture. The process parameters were found to affect the drug-release profile via two routes: (1) direct, through water uptake and swelling of the structure leading to FTS release, or through degradation of the host polymer leading to paclitaxel release at a later stage; (2) indirect effect of the microstructure on the release profile. The fabrication process did not reduce the pharmacological activity of either paclitaxel or FTS. FTS-eluting composite fibers proved to effectively induce growth inhibition or cell death by a gradient effect and do...Continue Reading

References

Sep 22, 1995·The Journal of Biological Chemistry·M MaromY Kloog
Apr 14, 1995·Journal of Medicinal Chemistry·D MarcianoY Kloog
Mar 7, 1998·Biochemistry·R HaklaiY Kloog
Jun 11, 1999·International Journal of Pharmaceutics·A B Dhanikula, R Panchagnula
Mar 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Feng, G Huang
May 23, 2001·Advanced Drug Delivery Reviews·J Siepmann, A Göpferich
Aug 1, 2002·The Journal of Biological Chemistry·Galit Elad-SfadiaYoel Kloog
Oct 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina FonsecaRogério Gaspar
Dec 20, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Mu, S S Feng
Jun 29, 2004·Seminars in Cancer Biology·Yoel Kloog, Adrienne D Cox
Oct 30, 2004·Journal of Biomedical Materials Research. Part a·Shrirang V RanadeMichael N Helmus
Nov 17, 2006·Journal of Interventional Cardiology·Suzan CommandeurWim J van der Giessen
Nov 28, 2006·Macromolecular Bioscience·Deepak ChitkaraAbraham J Domb
Jun 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Subbu Venkatraman, Freddy Boey
Jan 19, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amir KraitzerMeital Zilberman

❮ Previous
Next ❯

Citations

Dec 18, 2013·Therapeutic Delivery·Xiaolan ZhangSong Li
Mar 5, 2015·Biology of the Cell·Eya WolfsonRonit Pinkas-Kramarski
May 11, 2016·Biomaterials·Cristina NúñezCarlos Lodeiro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.