PMID: 8381247Jan 1, 1993Paper

Composite gastric carcinoma and precursor lesions with amphicrine features in chronic atrophic gastritis

Ultrastructural Pathology
G PasquinelliG N Martinelli


A composite carcinoma of the gastric body consisting of endocrine and mucous epithelial cells with interspersed amphicrine cells is reported together with ultrastructural and immunocytochemical documentation of endocrine and nonendocrine differentiation. The tumor was associated with hypergastrinemia related to chronic atrophic gastritis (achlorhydria) and with multiple proliferative lesions, such as intramucosal microcarcinoid (IMC) and endocrine cell proliferations of the micronodular and linear type, which are currently regarded as carcinoid precursor changes. Ultrastructurally, a composite architecture with amphicrine features was demonstrated in the primary tumor, IMC, and liver metastases. On the other hand, the endocrine cell proliferations exclusively contained gastrin and enterochromaffinlike cells. Immunostaining with antibodies to calcitonin documented a number of positive cells both in the primary and in the metastatic sites. This is the first report of mixed exocrine-endocrine-amphicrine components both in a metastasizing carcinoma and in its precursor lesions in a chronic hypergastrinemic state. Unlike previously reported lesions, the endocrine component was unexpectedly composed of calcitonin cells, which are not...Continue Reading


Dec 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J RothL Orci
Oct 25, 1975·British Medical Journal·R C CoombesA M Neville
Sep 1, 1975·British Journal of Cancer·M EllisonA M Neville
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·D SantiniG N Martinelli
Jun 1, 1991·The American Journal of Surgical Pathology·G C Yang, H Rotterdam
Dec 1, 1985·Cancer·G ChejfecV E Gould
Apr 1, 1987·The American Journal of Surgical Pathology·K AmbeM Enjoji
Apr 1, 1989·Journal of Clinical Pathology·S M SjöblomH J Järvinen
Jan 1, 1988·Digestion·W Creutzfeldt
Apr 1, 1988·Pathology, Research and Practice·G ChejfecV E Gould
Dec 1, 1987·The American Journal of Surgical Pathology·J MüllerH K Müller-Hermelink
Jan 1, 1986·Digestion·E SolciaL Villani
Feb 1, 1985·American Journal of Clinical Pathology·M Yamashina, R A Flinner
Nov 1, 1984·The American Journal of Surgical Pathology·C CapellaJ Rosai
Aug 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R A DeLellisH J Wolfe
Dec 1, 1983·Annals of Internal Medicine·J A CarneyF E Nora
Jun 1, 1980·The Journal of Clinical Endocrinology and Metabolism·L J Deftos
Jul 1, 1983·Ultrastructural Pathology·F CefisC Capella
May 1, 1984·Histopathology·M H AliJ G Azzopardi
Jul 1, 1980·Ultrastructural Pathology·C CapellaE Solcia


Mar 2, 2006·Virchows Archiv : an International Journal of Pathology·A MakinoR Chetty
Sep 22, 1999·Pathology Oncology Research : POR·L Mándoky
Oct 19, 2010·Annals of Diagnostic Pathology·Karthik GanesanMichael R Peterson
Mar 19, 2014·Alimentary Pharmacology & Therapeutics·R BasuroyJ K Ramage
Apr 29, 2016·American Journal of Clinical Pathology·Ethan B LudmirXuefeng Zhang
Aug 9, 2007·Virchows Archiv : an International Journal of Pathology·Marco VolanteM Papotti
Feb 24, 2015·Tumori·Alessandro GinoriSergio Antonio Tripodi
Nov 8, 2001·Archives of Pathology & Laboratory Medicine·J S Reis-Filho, F C Schmitt

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

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