Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood

Journal of Theoretical Biology
Daniel M KeenanJohannes D Veldhuis

Abstract

Blood-borne neurohormonal signals reflect the intermittent burst-like release of peptides and steroids from neurons, glands and target tissues. Hormones control basic physiological processes, such as growth, metabolism, reproduction and stress-related adaptations. Secreted molecules undergo combined diffusion, advection and irreversible elimination from the circulation. Quantification of these interdependent processes by a structurally relevant model embodying discrete event times, continuous rates of secretion and elimination, and stochastic variations poses a formidable challenge. In an experimental setting, one observes only the hormone concentrations, which comprise a time-varying composite of secretion and elimination. The number, shape and location of underlying bursts (pulses) and attendant secretion and kinetic parameters are unobserved. The ability to estimate the properties of these processes from the observed data is fundamental to an understanding of regulated hormonal dynamics. The present formulation allows objective simultaneous appraisal of discrete (pulse times) and continuous (secretion/elimination) properties of neuroglandular activity in the presence of random variability. A probability distribution is const...Continue Reading

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Oct 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Daniel M KeenanJohannes D Veldhuis
Nov 1, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M Keenan, Johannes D Veldhuis
Apr 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Daniel M KeenanJohannes D Veldhuis
Jun 10, 2004·American Journal of Physiology. Endocrinology and Metabolism·Daniel M KeenanJohannes D Veldhuis

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Citations

Aug 3, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ranganath MuniyappaMarc R Blackman
Jun 18, 2009·American Journal of Physiology. Endocrinology and Metabolism·Peter Y LiuJohannes D Veldhuis
Jun 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Johannes D VeldhuisDana Erickson
May 28, 2009·American Journal of Physiology. Endocrinology and Metabolism·Johannes D VeldhuisCyril Y Bowers
Feb 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Johannes D Veldhuis, Cyril Y Bowers
Sep 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johannes D VeldhuisJean R Wigham
Nov 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M KeenanJohannes D Veldhuis
Jul 10, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniel M Keenan, Johannes D Veldhuis
Oct 23, 2008·Endocrine Reviews·Johannes D VeldhuisSteven M Pincus
Jul 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Petra KokJohannes D Veldhuis
Sep 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Arthur WeltmanJohannes D Veldhuis
Nov 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisCacia Soares-Welch
Mar 1, 2012·PloS One·Ferdinand RoelfsemaJohannes D Veldhuis
Feb 4, 2014·PloS One·Rose T FaghihEmery N Brown
Aug 20, 2011·Endocrine Journal·Vladimir M MarkovićLjiljana Kolar-Anić
Aug 16, 2008·European Journal of Endocrinology·Johannes D Veldhuis, Daniel M Keenan
Aug 21, 2008·European Journal of Endocrinology·Ali Iranmanesh, Johannes D Veldhuis
Aug 23, 2012·European Journal of Endocrinology·Ferdinand RoelfsemaJohannes D Veldhuis
Mar 7, 2008·European Journal of Endocrinology·Lise AksglaedeAnders Juul
Mar 15, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catalina NormanJohannes D Veldhuis
Oct 8, 2008·Molecular and Cellular Endocrinology·Johannes D VeldhuisAjay X Nehra
Jul 15, 2015·Endocrine·Francesca Pecori Giraldi, Alberto G Ambrogio
Sep 15, 2012·Journal of Time Series Analysis·Daniel M KeenanJohannes D Veldhuis
Apr 11, 2017·Statistics in Medicine·K W HortonA J Polotsky
Jun 19, 2008·The Journal of Clinical Endocrinology and Metabolism·Petra KokHanno Pijl
Mar 4, 2006·Endocrinology·Daniel M KeenanJohannes D Veldhuis
Aug 10, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johannes D VeldhuisCyril Y Bowers
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Johannes D VeldhuisCyril Y Bowers
Nov 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Ben GibbisonStafford L Lightman
Oct 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Sjoerd D JoustraNadia Schoenmakers
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisCyril Y Bowers
Jan 26, 2006·Endocrine Reviews·Johannes D VeldhuisCyril Y Bowers
Dec 18, 2015·Physiology·Daniel M Keenan, Johannes D Veldhuis

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