Composite Nanoformulation Therapeutics for Long-Term Ocular Delivery of Macromolecules

Molecular Pharmaceutics
Vibhuti AgrahariAshim K Mitra

Abstract

The purpose of this investigation is to design and synthesize novel pentablock (PB) copolymer (PB-1: PCL-PLA-PEG-PLA-PCL) based nanoformulations suspended in a thermosensitive gelling copolymer (PB-2: mPEG-PCL-PLA-PCL-PEGm) termed as composite nanoformulation. The composite nanoformulation was prepared to provide a sustained delivery of macromolecules over a longer duration with negligible burst release effect. The delivery system was designed to be utilized for the treatment of posterior segment ocular diseases such as age-related (wet) macular degeneration, diabetic retinopathy, and diabetic macular edema. The novel PB copolymers were characterized for their functional groups by Fourier transform infrared spectroscopy, molecular weight and purity by (1)H NMR spectroscopy, and gel permeation chromatography. X-ray diffraction analysis was used to determine the crystallinity of copolymers. The size distribution of PB-1 nanoparticles (NPs) prepared using emulsification-solvent evaporation method was found to be ∼150 nm analyzed by nanoparticle tracking analysis. The % encapsulation efficiency and % drug loading were found to be 66.64% w/w ± 1.75 and 18.17% w/w ± 0.39, respectively, (n = 3). Different weight percentages (15 and 20...Continue Reading

References

Apr 12, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P Costa, J M Sousa Lobo
May 1, 2007·Ophthalmology·Sophie J BakriRavinder J Singh
Apr 9, 2010·Current Opinion in Ophthalmology·Kapil M Sampat, Sunir J Garg
Jan 6, 2012·Journal of Ophthalmology·Pearse A Keane, Srinivas R Sadda
Apr 24, 2012·Journal of Ophthalmology·Jaclyn L KovachIngrid U Scott
May 2, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ying Zhang, Steven P Schwendeman
Jan 24, 2013·Therapeutic Advances in Chronic Disease·Matthew Ohr, Peter K Kaiser
Apr 18, 2014·Journal of Immunology Research·Francisco Rosa StefaniniMaurício Maia
May 28, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Indu Pal Kaur, Shilpa Kakkar
Jun 17, 2014·Expert Opinion on Drug Delivery·Sachin S ThakurHarendra S Parekh
Jan 13, 2015·Current Topics in Medicinal Chemistry·Silvia PescinaSara Nicoli
Oct 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vianney DelplaceMolly Shoichet

❮ Previous
Next ❯

Citations

Aug 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pakama MahlumbaViness Pillay
Jul 28, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jianing MengIbrahima Youm
Feb 23, 2017·Therapeutic Delivery·Vibhuti AgrahariAshim K Mitra
Dec 15, 2016·Expert Opinion on Drug Delivery·Vibhuti AgrahariAshim K Mitra
Aug 23, 2019·Biomaterials Science·Young Ju SonHyuk Sang Yoo
Jun 19, 2019·Nanomaterials·Simona SapinoMarina Gallarate
Apr 3, 2020·Biological & Pharmaceutical Bulletin·Ryosuke Fukuda, Tatsuya Murakami
May 17, 2017·Advanced Pharmaceutical Bulletin·Mitra Alami-MilaniMitra Jelvehgari
Nov 29, 2017·Drug Delivery and Translational Research·Vibhuti AgrahariAshim K Mitra
Feb 5, 2021·Pharmaceutics·Sylwia ŁukasiewiczMarta Dziedzicka-Wasylewska
Jan 18, 2018·Advanced Drug Delivery Reviews·Abhirup MandalAshim K Mitra
Jun 12, 2017·ACS Biomaterials Science & Engineering·Yangzi TianYubing Xie
Jun 3, 2020·Molecular Pharmaceutics·Pengfei JiangKatelyn E Swindle-Reilly
Mar 25, 2016·Therapeutic Delivery·Vibhuti AgrahariAshim K Mitra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.