Composite poly-L-lactic acid/poly-(α,β)-DL-aspartic acid/collagen nanofibrous scaffolds for dermal tissue regeneration

Materials Science & Engineering. C, Materials for Biological Applications
Rajeswari RavichandranSeeram Ramakrishna

Abstract

Tissue engineering scaffolds for skin tissue regeneration is an ever expounding area of research, as the products that meet the necessary requirements are far and elite. The nanofibrous poly-L-lactic acid/poly-(α,β)-DL-aspartic acid/Collagen (PLLA/PAA/Col I&III) scaffolds were fabricated by electrospinning and characterized by SEM, contact angle and FTIR analysis for skin tissue regeneration. The cell-scaffold interactions were analyzed by cell proliferation and their morphology observed in SEM. The results showed that the cell proliferation was significantly increased (p≤0.05) in PLLA/PAA/Col I&III scaffolds compared to PLLA and PLLA/PAA nanofibrous scaffolds. The abundance and accessibility of adipose derived stem cells (ADSCs) may prove to be novel cell therapeutics for dermal tissue regeneration. The differentiation of ADSCs was confirmed using collagen expression and their morphology by CMFDA dye extrusion technique. The current study focuses on the application of PLLA/PAA/Col I&III nanofibrous scaffolds for skin tissue engineering and their potential use as substrate for the culture and differentiation of ADSCs. The objective for inclusion of a novel cell binding moiety like PAA was to replace damaged extracellular matrix...Continue Reading

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Citations

Sep 4, 2013·Journal of Materials Science. Materials in Medicine·Rajeswari RavichandranSeeram Ramakrishna
Apr 9, 2013·Nanomedicine·Rúben F PereiraPaulo J Bartolo
Dec 5, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Fateme Ahmadi-AghkandAbolfazl Akbarzadeh
Oct 28, 2014·Journal of Biomedical Materials Research. Part a·Mohammad NorouziMasoud Soleimani
Nov 30, 2016·International Journal of Molecular Sciences·Atul A ChaudhariShreekumar R Pillai
Apr 15, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Farideh MohammadianAbolfazl Akbarzadeh
Oct 8, 2014·Biomedical Engineering and Computational Biology·Khalil N Bitar, Elie Zakhem
Mar 19, 2019·Expert Opinion on Biological Therapy·Elie ZakhemKhalil N Bitar
May 1, 2013·Journal of Biomedical Materials Research. Part a·Leah GarberDaniel Hayes
Jun 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nuno H C S SilvaArmando J D Silvestre
Feb 28, 2015·Advanced Healthcare Materials·Mohammad NorouziMasoud Soleimani
Jul 24, 2021·Biomaterials Science·Subarna RayHang T Ta

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