Composite poly(lactic acid)/chitosan nanofibrous scaffolds for cardiac tissue engineering

International Journal of Biological Macromolecules
Yaowen LiuRong Zhang

Abstract

Fibrous scaffolds with different ratios of poly (lactic acid) (PLA) and chitosan were fabricated by conventional electrospinning. After crosslinking by the glutaraldehyde vapor, the structure, mechanical properties, hydrophilicity, and in-fiber chemical interactions of the scaffolds were investigated. We found that the fiber diameter decreased with the concentration of chitosan, while mechanical properties and hydrophilicity improved. In addition, we found that scaffolds with aligned fibers have higher mechanical strength and biocompatibility than scaffolds with randomly oriented fibers. In particular, scaffolds with aligned fibers with PLA:chitosan ratios of 7:1 was found to support cardiomyocyte viability, elicit cell elongation, and enhance production of sarcomeric α-actinin and troponin I. Collectively, the data indicate that composite scaffolds consisting of PLA/chitosan fibers have great potential for engineering cardiac tissue, and for accelerating the regeneration of myocardia.

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Citations

Jan 23, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Farbod TondnevisJamshid Aghazadeh Mohandesi
Feb 16, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Diana Gabriela SoaresCarlos Alberto de Souza Costa
Apr 27, 2018·Journal of the Royal Society, Interface·Mathew BaldwinAndrew Carr
Apr 10, 2019·Polymers·Moustafa M ZaghoAhmed A Elzatahry
Jul 2, 2020·International Journal of Nanomedicine·Saeed Mohammadi NasrThomas J Webster
Jan 1, 2020·Carbohydrate Polymers·Fenghua TaoHongbing Deng
Oct 30, 2020·International Journal of Biological Macromolecules·A A SukhanovaA V Shabanov

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