Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study

Transplant International : Official Journal of the European Society for Organ Transplantation
Daniela ZahnHeike Spaderna

Abstract

We evaluated two composite risk scores, (Heart Failure Survival Score, HFSS; German Transplant Society Score, GTSS), and depression as predictors of mortality and competing waiting-list outcomes [high-urgency transplantation (HU-HTx), elective transplantation, delisting because of clinical improvement] in 318 heart transplant (HTx) candidates (18% women; aged 53 ± 11 years) from 17 hospitals and newly registered with Eurotransplant. Demographic variables and depression (Hospital Anxiety and Depression Scale, HADS) were assessed using questionnaires. Variables to compute HFSS and GTSS, age, medications, and outcomes were provided by Eurotransplant. At 12 months, 33 patients died, 83 received urgent HTx, 30 elective HTx, and 17 were delisted because of improvement. Applying cause-specific Cox regressions, only the HFSS was significantly associated with 1-year mortality [HR = 0.64 (95% CI = 0.43-0.95), P = 0.029]. The GTSS was the strongest predictor of HU-HTx [HR= 1.02 (95% CI = 1.01-1.02), P < 0.001]. Low depression scores contributed significantly to clinical improvement, even after adjusting for age and risk scores [HADS: HR = 0.12 (95% CI = 0.02-0.89), P = 0.039]. These findings confirm the usefulness of composite risk scores...Continue Reading

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Citations

May 22, 2016·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Kathleen GaliGerdi Weidner
Dec 1, 2017·Journal of the American Heart Association·Heike SpadernaGerdi Weidner
Jun 4, 2019·Southern Medical Journal·David SnipeliskyM Caroline Burton
Dec 14, 2016·AACN Advanced Critical Care·Catherine Murks, Colleen Juricek
Nov 21, 2019·Journal of Religion and Health·Sepideh TaghaviYasaman Khalili
Jul 9, 2011·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Gerdi WeidnerUNKNOWN Waiting for a New Heart Study Group

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