Composite vascularized skin/bone transplantation models for bone marrow-based tolerance studies

Annals of Plastic Surgery
Selahattin OzmenMaria Siemionow

Abstract

There is an ongoing need to understand the mechanisms of bone marrow-based allograft tolerance. This is important in clarifying the diverse variables influencing the ultimate outcome of the solid organ and composite tissue transplants. To establish bone marrow transplantation as a routine clinical application, further experimental studies should be conducted to overcome the obstacles related to the bone marrow transplantation. These obstacles include graft versus host disease, immunocompetence, and toxicity of the conditioning regimens. For these purposes, novel experimental models are needed. In an attempt to provide a reliable research tool for bone marrow-based tolerance induction studies, we introduced different experimental models of modified vascularized skin/bone marrow (VSBM) transplantation technique for tolerance induction, monitoring, and maintenance studies. In this skin/bone transplantation model, the technical feasibility of concurrent or consecutive transplantation of the combination of bilateral vascularized skin, vascularized bone marrow, or vascularized skin/bone marrow transplants was investigated. Isograft transplantations were performed between genetically identical Lewis (LEW, RT1) rats. Five different exp...Continue Reading

References

Jun 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T E StarzlJ J Fung
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·B LukomskaW L Olszewski
Dec 1, 1996·Immunology Today·T E StarzlA S Rao
Feb 1, 1997·Transplantation Proceedings·C RicordiA G Tzakis
Apr 28, 1999·Lancet·J M DubernardN S Hakim
Jul 29, 1999·The Journal of Surgical Research·S R CoberW P Lee
Jan 22, 2000·The Journal of Clinical Investigation·C A HuangD H Sachs
Aug 19, 2000·The New England Journal of Medicine·J W JonesW C Breidenbach
Sep 30, 2000·Clinical and Experimental Dermatology·M CumberbatchI Kimber
Mar 27, 2001·Transplantation Proceedings·A P Monaco
May 22, 2001·Bone Marrow Transplantation·D LysákS Vokurka
Jun 2, 2001·The New England Journal of Medicine·M StromeJ Mayes
Jul 4, 2001·Bone Marrow Transplantation·R ChamplinS Giralt
Jul 5, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stephen R Smith, David W Butterly
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarW D Payne
Jul 19, 2002·Archives of Internal Medicine·Imad A TabbaraZeina Nahleh
Aug 29, 2002·Clinical and Experimental Immunology·S JollesA Ager

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Citations

Nov 1, 2007·Seminars in Plastic Surgery·Maria Siemionow, Yalcin Kulahci
Jan 9, 2010·Plastic and Reconstructive Surgery·Maria Z SiemionowMehmet Bozkurt
Sep 3, 2010·Plastic and Reconstructive Surgery·Robert SucherStefan Schneeberger
May 19, 2010·The Journal of Surgical Research·Betul Gozel UlusalChun-Yen Lin
May 1, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SiemionowK Carnevale
Mar 26, 2008·Annals of Plastic Surgery·Maria Siemionow, Serdar Nasir
Mar 17, 2011·The Journal of the American Academy of Orthopaedic Surgeons·Maria Siemionow
Oct 10, 2012·Annals of Plastic Surgery·Maria SiemionowJoanna Cwykiel
May 11, 2021·Archivum Immunologiae Et Therapiae Experimentalis·Joanna CwykielMaria Siemionow

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