Composition and anti-inflammatory effect of polysaccharides from Sargassum horneri in RAW264.7 macrophages

International Journal of Biological Macromolecules
Zheng-Shun WenYou-Le Qu

Abstract

Sulfated polysaccharides extracted from brown marine algae have been shown to possess a variety of biological activities. We assessed the potential activity of the sulfated polysaccharide from Sargassum horneri (SP) and its isolated two major components (fraction-1 (F1) and fraction-2 (F2)), on anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In the present study, analysis of polysaccharide chemical composition found that the constituent ratios of sulfate ester and fucose in SP and F1 were 4.95% vs 7.6%, and 4.48% vs 55.9%, respectively, suggesting that F1 may be a major sulfated polysaccharide containing fucose. Meanwhile, our findings demonstrated that TNF-α secretion levels were significantly (P<0.05) decreased by SP and F1 treatments in LPS-stimulated RAW264.7 cells in a dose-dependent manner under the preventive and repair experimental models. Pro-/anti-inflammatory (TNF-α/IL-10) cytokines secretion ratios by LPS-stimulated RAW264.7 macrophages were significantly (P<0.05) inhibited by SP and F1 treatments, particularly by F1 (at high dose, 200μg/ml). Moreover, NO release and iNOS activity were significantly (P<0.05) inhibited by F1. Collectively, the present study suggested that purif...Continue Reading

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Citations

Aug 3, 2016·Marine Drugs·Lucas CholletFrédéric Chaubet
Feb 14, 2017·International Journal of Biological Macromolecules·Xin LiuMingyong Xie
Jul 22, 2017·International Journal of Biological Macromolecules·Zhe RenYifan Huang
Mar 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wansha YuNingjia He
Nov 28, 2018·International Journal of Molecular Sciences·Ye Eun Jeong, Mi-Young Lee
May 10, 2020·BioMed Research International·Kazunori SasakiHiroko Isoda
Jul 11, 2019·Polymers·Joanne Katherine Talens ManlusocPo-Wei Tsai
Jul 22, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Claudia Juárez-PortillaRossana C Zepeda
May 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Su Bin ParkJin Boo Jeong
Jun 14, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Zhihua HuangCheng Huang
Feb 24, 2019·International Journal of Biological Macromolecules·M DutotP Devillier
Apr 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen Hai-LanHu Ting-Jun

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