Abstract
Sulfated polysaccharides extracted from brown marine algae have been shown to possess a variety of biological activities. We assessed the potential activity of the sulfated polysaccharide from Sargassum horneri (SP) and its isolated two major components (fraction-1 (F1) and fraction-2 (F2)), on anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In the present study, analysis of polysaccharide chemical composition found that the constituent ratios of sulfate ester and fucose in SP and F1 were 4.95% vs 7.6%, and 4.48% vs 55.9%, respectively, suggesting that F1 may be a major sulfated polysaccharide containing fucose. Meanwhile, our findings demonstrated that TNF-α secretion levels were significantly (P<0.05) decreased by SP and F1 treatments in LPS-stimulated RAW264.7 cells in a dose-dependent manner under the preventive and repair experimental models. Pro-/anti-inflammatory (TNF-α/IL-10) cytokines secretion ratios by LPS-stimulated RAW264.7 macrophages were significantly (P<0.05) inhibited by SP and F1 treatments, particularly by F1 (at high dose, 200μg/ml). Moreover, NO release and iNOS activity were significantly (P<0.05) inhibited by F1. Collectively, the present study suggested that purif...Continue Reading
References
Dec 16, 1983·Journal of Immunological Methods·T Mosmann
Sep 25, 2001·Lancet·D M Lee, M E Weinblatt
Jan 6, 2006·The New England Journal of Medicine·Gary S Firestein
May 2, 2006·Nitric Oxide : Biology and Chemistry·Ebru Karpuzoglu, S Ansar Ahmed
Jul 7, 2009·The Journal of Nutritional Biochemistry·Hang DoEun-Hwa Sohn
Oct 6, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Subash AnanthiHannah R Vasanthi
Mar 20, 2010·World Journal of Gastroenterology : WJG·Palash MandalLaura E Nagy
Dec 18, 2010·Lipids in Health and Disease·Asaf A QureshiNilofer Qureshi
Oct 14, 2011·Lipids in Health and Disease·Asaf A QureshiNilofer Qureshi
Citations
Jul 2, 2016·Marine Drugs·Donghai ZhaoJianhui Cai
Aug 3, 2016·Marine Drugs·Lucas CholletFrédéric Chaubet
Oct 11, 2016·Indian Journal of Pharmacology·Yuvaraj Neelakandan, Arul Venkatesan
Feb 14, 2017·International Journal of Biological Macromolecules·Xin LiuMingyong Xie
Jul 22, 2017·International Journal of Biological Macromolecules·Zhe RenYifan Huang
Oct 20, 2019·Marine Drugs·UNKNOWN SaraswatiNuri Andarwulan
Mar 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wansha YuNingjia He
Nov 14, 2019·BMC Complementary and Alternative Medicine·Ha Na KimJin Boo Jeong
Nov 16, 2016·Journal of Medicinal Food·Sun-Ji OhHyeung-Rak Kim
Dec 28, 2017·Experimental Dermatology·Mehdi SakkaNicolas Lebonvallet
Nov 28, 2018·International Journal of Molecular Sciences·Ye Eun Jeong, Mi-Young Lee
Jun 14, 2020·Environmental Science and Pollution Research International·Gamal RamadanWael M Ibrahim
Apr 30, 2019·Food & Function·Chao TangChanghai Jin
May 10, 2020·BioMed Research International·Kazunori SasakiHiroko Isoda
Jul 29, 2020·Scientific Reports·Fangyuan HuYaqing Chang
Sep 12, 2018·BMC Complementary and Alternative Medicine·Thilina U JayawardenaYou-Jin Jeon
Dec 11, 2019·Marine Drugs·Menglu XiaYanbin Lu
Jul 11, 2019·Polymers·Joanne Katherine Talens ManlusocPo-Wei Tsai
Nov 22, 2020·Food & Function·Yingjuan LiuYunliang Guo
Jul 22, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Claudia Juárez-PortillaRossana C Zepeda
Nov 10, 2020·International Journal of Biological Macromolecules·Xiaopan LiuTao Qin
May 15, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Su Bin ParkJin Boo Jeong
Jun 14, 2019·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Zhihua HuangCheng Huang
Feb 24, 2019·International Journal of Biological Macromolecules·M DutotP Devillier
May 1, 2021·Marine Drugs· SaraswatiNuri Andarwulan
Jun 4, 2021·Bioorganic Chemistry·Si-Yuan ShaoPei-Cheng Zhang
Aug 25, 2021·Journal of Food Biochemistry·Zhi-Chang LiuHong-Bin Liu
Apr 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen Hai-LanHu Ting-Jun
Nov 26, 2020·Food Research International·Tian JiangYubao Li