PMID: 8586781Jun 1, 1995Paper

Composition and preliminary evaluation of a hydrolyzed rice-based oral rehydration solution for the treatment of acute diarrhea in children

Journal of the American College of Nutrition
E LebenthalA Bakri

Abstract

The purpose of this study was to experimentally develop and clinically evaluate the safety and potential usefulness of a rice-based, short glucose polymer oral rehydration solution (ORS), Amylyte, in the treatment of acute diarrhea. Amylyte has a similar osmolality but a higher caloric density than the WHO ORS. Different amounts of rice were cooked in 500 ml of water containing salts (1.5 g NaCl, 600 mg KCl, and 150 mg CaCl2) with varying amounts of thermophilic amylase (252,500 modified Wohlgemuth units). Amylase (25 mg) thinned the gluey rice water when 100 g of rice was cooked in 500 ml of water for 10 minutes. The volume of the resultant supernatant (Amylyte) was approximately 250 ml. A two-part, clinical case study was performed. In study 1, 12 children with diarrhea and mild dehydration were studied to determine the safety of Amylyte. In study 2, Amylyte and the WHO ORS were given to 24 and 31 male children with acute diarrhea and moderate to severe dehydration, respectively. 92-96% of the rice amylose and amylopectin were converted to short polymers of glucose (3-9 molecules of glucose). The osmolality of 7,994 packages used to make the Amylyte solution ranged between 277-340 mOsm/kg. The mean electrolyte composition was...Continue Reading

References

Apr 1, 1978·Archives of Disease in Childhood·A ChatterjeeD K Bagchi
Apr 1, 1991·The Journal of Pediatrics· Khin-Maung-U, W B Greenough
Aug 1, 1990·Pediatric Research·M A Azad, E Lebenthal
Sep 27, 1990·The New England Journal of Medicine·M E Avery, J D Snyder
Nov 1, 1984·Archives of Disease in Childhood·M R Islam, S M Ahmed

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Citations

Jul 20, 2007·The Cochrane Database of Systematic Reviews·O FontaineN F Pierce
Dec 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N D SonawaneA S Verkman
Dec 14, 2016·The Cochrane Database of Systematic Reviews·Germana V GregorioElizabeth G Martinez
Apr 2, 2010·International Journal of Epidemiology·Melinda K MunosRobert E Black
Mar 9, 2011·Reviews in Medical Virology·Alexandre C LinharesRomulo Colindres
Apr 26, 2018·The Cochrane Database of Systematic Reviews·Giordano Pérez-GaxiolaVíctor M Pérez-Pico

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