Composition-Engineered Metal-Organic Framework-Based Microneedles for Glucose-Mediated Transdermal Insulin Delivery

ACS Applied Materials & Interfaces
Xiao-Xi YangYu Tang

Abstract

Elaborately designed glucose-responsive insulin-delivery systems are highly desirable for the treatment of diabetes because it can secrete insulin depending on blood glucose levels. Herein, mimic multi-enzyme metal-organic framework (MOF)-based (insulin and glucose oxidase-loaded cobalt-doped ZIF-8, abbreviated as Ins/GOx@Co-ZIF-8) stimuli-responsive microneedles (MNs) were designed for painless glucose-mediated transdermal administration. In this work, GOx and Co2+ ions were engineered into MOFs to construct a mimic multi-enzyme vehicle. GOx in the MOF, as the glucose-responsive factor, could catalyze glucose into gluconic acid with the formation of H2O2 as the byproduct. The gluconic acid formed decreases the local pH in MOFs, resulting in the degradation of MOFs and thus preloaded insulin would be released. Meanwhile, catalyzed by Co2+ ions in the MOF, the byproduct H2O2 was decomposed. Possible free Co2+ ions would be chelated by EDTA-SiO2 nanoparticles in MNs and removed by peeling MNs off. The as-obtained mimic multi-enzyme MOF-based MNs showed good dependence on glucose concentration without divulging H2O2 and Co2+ ions and enough stiffness to penetrate into skin. This study offers a new strategy, using facilely synthesi...Continue Reading

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Citations

Jul 25, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jieying Liang, Kang Liang
Jul 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Minglong ChenChuanbin Wu
Apr 17, 2021·International Journal of Pharmaceutics·Ruxuan WangJianqing Gao
Aug 28, 2021·Advanced Healthcare Materials·Li ZhaoRyan F Donnelly
Aug 31, 2021·ACS Applied Materials & Interfaces·Md Rafiqul IslamMasahiro Goto
Oct 30, 2021·Chemical Communications : Chem Comm·Pei-Hong TongTony D James

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