Composition of fecal microbiota in low-set rectal cancer patients treated with FOLFOX

Therapeutic Advances in Chronic Disease
Jing LiBaoli Zhu

Abstract

FOLFOX treatment is a method used widely to reduce tumor size in low-set rectal cancer, with variable clinical results. FOLFOX agents comprise a mixture of oxaliplatin and 5-fluorouracil, the efficacy of which might be modulated by the gut microbiome in humans. This study aimed to determine whether the bowel microbiota is a factor that influences FOLFOX treatment. To investigate the role of gut microbiota during FOLFOX treatment, we carried out comprehensive metagenomic and metabolomic analyses on 62 fecal samples collected from 37 low-set rectal cancer patients. A set of 31 samples was collected before the patients underwent treatment; another 31 samples were obtained after the treatment was completed. Among these samples, 50 were paired samples collected before and after FOLFOX treatment. The patients were divided into responder and nonresponder groups according to the treatment outcome. Metagenomic sequencing was performed on these fecal samples. Diverse bacterial taxa were identified by MetaGeneMark, Soapaligner, and DIAMOND; microbiotal data analyses were carried out in the R environment. Differences in microbial taxa and metagenomic linkage groups were observed in multiple comparative analyses. The gut microbiota was alte...Continue Reading

References

Oct 6, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C H KoehneD J Kerr
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S GiacchettiF Lévi
Oct 18, 2001·Anti-cancer Drugs·P G Johnston, S Kaye
Nov 6, 2004·Journal of Clinical Microbiology·Sydney M FinegoldHannele Jousimies-Somer
Aug 8, 2006·Journal of Clinical Microbiology·Susanna K P LauKwok-Yung Yuen
Jul 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter H O'Donnell, M Eileen Dolan
Oct 17, 2009·Oral Microbiology and Immunology·R FujiiK Ishihara
Jan 15, 2010·Journal of Clinical Microbiology·Guili ZhengSydney M Finegold
Jul 22, 2010·The American Journal of Gastroenterology·Chin Wen PngTimothy H J Florin
Apr 29, 2011·Journal of Clinical Microbiology·Rune Micha PedersenUlrik Stenz Justesen
Oct 20, 2011·Genome Research·Mauro CastellarinRobert A Holt
Oct 20, 2011·Genome Research·Aleksandar D KosticMatthew Meyerson
Dec 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sharon GreenblumElhanan Borenstein
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Aug 21, 2012·Science·Janelle C ArthurChristian Jobin
May 31, 2013·Nature·Fredrik H KarlssonFredrik Bäckhed
Oct 18, 2013·Nature Reviews. Cancer·Robert F Schwabe, Christian Jobin
Dec 3, 2014·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zuzana KozovskaLucia Kucerova
Mar 12, 2015·Nature Communications·Qiang FengJun Wang
Apr 4, 2015·Science·Wendy S Garrett
May 15, 2015·Cell Host & Microbe·Fredrik BäckhedWang Jun
Sep 1, 2015·Carcinogenesis·Celia DingemanseEls C Robanus-Maandag
Oct 31, 2015·Nature Communications·Geicho NakatsuJoseph J Y Sung
Nov 7, 2015·Science·Marie VétizouLaurence Zitvogel
Dec 9, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven M Offer, Robert B Diasio
Jul 6, 2016·British Journal of Cancer·Julia L DrewesCynthia L Sears
Oct 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qiaoyi LiangJun Yu

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Datasets Mentioned

BETA
PRJNA484031

Methods Mentioned

BETA
chemical therapy
PCA

Software Mentioned

SOAP denovo
clusterSim
ade4
MetaPhlAn2
MEGAN
SoapAligner
SOAP2
vegan
cluster
MetaGeneMark

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