Composition of gut microbiota and its influence on the immunogenicity of oral rotavirus vaccines

Vaccine
Cliff A Magwira, Maureen B Taylor

Abstract

The introduction of oral rotavirus vaccines (ORVVs) has led to a reduction in number of hospitalisations and deaths due to rotavirus (RV) infection. However, the efficacy of the vaccines has been varied with low-income countries showing significantly lower efficacy as compared to high-income countries. The reasons for the disparity are not fully understood but are thought to be multi-factorial. In this review article, we discuss the concept that the disparity in the efficacy of oral rotavirus vaccines between the higher and lower socio-economical countries could be due the nature of the bacteria that colonises and establishes in the gut early in life. We further discuss recent studies that has demonstrated significant correlations between the composition of the gut bacteria and the immunogenicity of oral vaccines, and their implications in the development of novel oral RV vaccines or redesigning the current ones for maximum impact.

Citations

Jul 25, 2019·Frontiers in Microbiology·Annalisa CiabattiniDonata Medaglini
Aug 14, 2019·Cells·Ignasi Azagra-BoronatMaria J Rodríguez-Lagunas
Nov 6, 2020·Vaccines·Rossella CianciGiovanni Gambassi
Dec 17, 2020·Frontiers in Pediatrics·Candice E RuckKinga K Smolen
Feb 12, 2021·Nature Reviews. Immunology·Kelsey E HuusB Brett Finlay
Nov 3, 2020·Virus Research·Faizan Ahmed Sadiq
May 28, 2021·Frontiers in Immunology·Elena GonçalvesBehazine Combadière
Jul 6, 2021·Expert Review of Vaccines·Debasish SahaSelim Badur
Aug 6, 2021·Current Microbiology·Zhiming LvZeliang Chen

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