Composition of symbiotic bacteria predicts survival in Panamanian golden frogs infected with a lethal fungus

Proceedings. Biological Sciences
Matthew H BeckerBrian Gratwicke

Abstract

Symbiotic microbes can dramatically impact host health and fitness, and recent research in a diversity of systems suggests that different symbiont community structures may result in distinct outcomes for the host. In amphibians, some symbiotic skin bacteria produce metabolites that inhibit the growth of Batrachochytrium dendrobatidis (Bd), a cutaneous fungal pathogen that has caused many amphibian population declines and extinctions. Treatment with beneficial bacteria (probiotics) prevents Bd infection in some amphibian species and creates optimism for conservation of species that are highly susceptible to chytridiomycosis, the disease caused by Bd. In a laboratory experiment, we used Bd-inhibitory bacteria from Bd-tolerant Panamanian amphibians in a probiotic development trial with Panamanian golden frogs, Atelopus zeteki, a species currently surviving only in captive assurance colonies. Approximately 30% of infected golden frogs survived Bd exposure by either clearing infection or maintaining low Bd loads, but this was not associated with probiotic treatment. Survival was instead related to initial composition of the skin bacterial community and metabolites present on the skin. These results suggest a strong link between the ...Continue Reading

References

Mar 12, 1999·Journal of Wildlife Diseases·S K TaylorA C Pier
Feb 7, 2001·The American Journal of Clinical Nutrition·A Bezkorovainy
Feb 14, 2003·Lancet·Francisco Guarner, Juan-R Malagelada
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mari Yotsu-YamashitaJohn W Daly
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Michael W TaylorMichael Wagner
Jun 27, 2007·ILAR Journal·Christine L Densmore, David Earl Green
Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
Mar 17, 2009·Die Naturwissenschaften·Nobutaka Someya, Katsumi Akutsu
Mar 27, 2009·The ISME Journal·Reid N HarrisKevin P C Minbiole
Sep 1, 2009·Applied and Environmental Microbiology·Matthew H BeckerKevin P C Minbiole
Dec 24, 2009·Physiologia Plantarum·James F White, Mónica S Torres
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Nov 9, 2010·Conservation Biology : the Journal of the Society for Conservation Biology·Vidya AthreyaK Ullas Karanth
Nov 30, 2010·Nature Reviews. Microbiology·Gregor ReidHenk J Busscher
Mar 30, 2011·Environmental Microbiology·Nicole S Webster, Michael W Taylor
Jun 24, 2011·The Journal of Investigative Dermatology·Richard L Gallo, Teruaki Nakatsuji
Aug 6, 2011·Integrative and Comparative Biology·Louise A Rollins-SmithDouglas C Woodhams
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Anna E Savage, Kelly R Zamudio
Oct 1, 2011·The ISME Journal·Valerie J McKenzieChristian L Lauber
Apr 20, 2012·Journal of Animal Physiology and Animal Nutrition·S MohapatraK N Mohanta
Jul 28, 2012·Science·Shruti NaikYasmine Belkaid
Nov 20, 2012·FEMS Microbiology Reviews·Suhelen EganTorsten Thomas
Feb 1, 2013·Proceedings. Biological Sciences·Cory J KredietMax Teplitski
Mar 9, 2013·British Dental Journal·J Loudon
Mar 29, 2013·The American Naturalist·Hermógenes Fernández-MarínWilliam T Wcislo
Nov 19, 2013·Trends in Microbiology·Nina N Schommer, Richard L Gallo
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrea J Jani, Cheryl J Briggs

❮ Previous
Next ❯

Citations

Sep 23, 2016·Proceedings. Biological Sciences·Jordan G KuenemanValerie J McKenzie
Sep 9, 2016·PLoS Pathogens·Jenifer B Walke, Lisa K Belden
Apr 19, 2017·Environmental Microbiology·Joana Sabino-PintoMiguel Vences
Jan 31, 2018·Conservation Biology : the Journal of the Society for Conservation Biology·Alexandra L DeCandiaBridgett M vonHoldt
Nov 25, 2017·Scientific Reports·Courtney A ThomasonDana M Hawley
Feb 19, 2017·Applied and Environmental Microbiology·Carly R Muletz-WolzKaren R Lips
Feb 17, 2018·Nature Communications·Kieran A BatesXavier A Harrison
May 9, 2019·The ISME Journal·Donald M WalkerMatthew C Allender
Dec 8, 2017·Proceedings. Biological Sciences·Amanda C PerofskyLauren Ancel Meyers
Jun 24, 2017·Proceedings. Biological Sciences·Andrea J JaniCheryl J Briggs
Apr 29, 2020·Ecological Applications : a Publication of the Ecological Society of America·Sara C BellLee F Skerratt
Nov 19, 2015·Frontiers in Microbiology·Lisa K BeldenReid N Harris
Aug 24, 2018·Proceedings. Biological Sciences·Molly C BletzAn Martel
Nov 30, 2019·Frontiers in Microbiology·Liza Garcia-RecinosMaria Dominguez-Bello
Sep 6, 2017·Frontiers in Microbiology·Carly R Muletz-WolzKaren R Lips
Dec 12, 2018·Microbial Ecology·Molly A AlbeckerMichael W McCoy
Nov 27, 2018·Frontiers in Immunology·Laura F GroganHamish I McCallum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Protein Structures

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.

Bacterial Protein Structures (ASM)

Bacterial protein structures can expedite the development of novel antibiotics. Here is the latest research on bacterial proteins and the resolution of their structures.