Compositional and histological comparison of carbonate apatite fabricated by dissolution-precipitation reaction and Bio-Oss®

Journal of Materials Science. Materials in Medicine
Kenji FujisawaYouji Miyamoto

Abstract

Carbonate apatite (CO3Ap) is an inorganic component of bone. This study aimed to compare the composition and tissue response to of CO3Ap (CO3Ap-DP) fabricated by the dissolution-precipitation reaction using calcite as a precursor and Bio-Oss®, which is widely used in orthopedic and dental fields as a synthetic bone substitute. X-ray diffraction and Fourier transform infrared results showed that CO3Ap-DP and Bio-Oss® were both B-type carbonate apatite with low crystallinity. The average sizes of CO3Ap-DP and Bio-Oss® granules were 450 ± 58 and 667 ± 168μ m, respectively, and their carbonate contents were 12.1 ± 0.6 and 5.6 ± 0.1 wt%, respectively. CO3Ap-DP had a larger amount of CO3 than Bio-Oss® but higher crystallinity than Bio-Oss®. When a bone defect made at the femur of rabbits was reconstructed with CO3Ap-DP and Bio-Oss®, CO3Ap-DP granules were partially replaced with bone, whereas Bio-Oss® remained at 8 weeks after implantation. CO3Ap-DP granules elicited a significantly larger amount of new bone formation at the cortical bone portion than Bio-Oss® at 4 weeks after the implantation. The results obtained in the present study demonstrated that CO3Ap-DP and Bio-Oss® showed different behavior even though they were both classi...Continue Reading

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Citations

Feb 2, 2019·Journal of Biomedical Materials Research. Part a·Kunio IshikawaYouji Miyamoto
Nov 23, 2019·Journal of Biomedical Materials Research. Part a·Kazuya AkitaYouji Miyamoto
Jul 11, 2020·Advanced Biosystems·Koichiro HayashiKunio Ishikawa
Jan 1, 2019·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Keiko KudohYouji Miyamoto
Aug 27, 2021·Science and Technology of Advanced Materials·Kunio Ishikawa, Koichiro Hayashi

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