Compounds for imaging amyloid-β deposits in an Alzheimer's brain: a patent review

Expert Opinion on Therapeutic Patents
Peiyu TuMengchao Cui

Abstract

β-amyloid (Aβ) plaques in the brain are regarded as a hallmark of Alzheimer's disease (AD), and the imaging of Aβ is a critical step for early diagnosis. Extensive research has been done to develop probes for targeting Aβ with available imaging modalities. In this review, the authors give an overview of published patents and papers about the discovery and development of compounds possessing potential utilization in imaging Aβ for the diagnosis of AD. SciFinder is the main electronic database for patent study in this review. Despite achievements in Aβ imaging, there is still a need to develop innovative compounds with selectivity and high affinity to Aβ. Positron emission tomography imaging agents will still be the trend in the field in the short term. Due to the low costs for single-photon emission computed tomography (SPECT) and the excellent nuclear properties of (99m)Tc, substantial research should be conducted on the development of the probes for SPECT. Refining the current imaging techniques and in the meantime developing new efficient imaging multimodality and compounds would be a promising approach to imaging Aβ.

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Citations

May 4, 2018·Neural Regeneration Research·Min ChenKun Zhang
Oct 28, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Alicia López-de-EguiletaAlfonso Casado
May 23, 2020·Nutritional Neuroscience·Raffaella Adami, Daniele Bottai
Aug 18, 2017·JCI Insight·Yosef KoronyoMaya Koronyo-Hamaoui
Sep 22, 2020·PloS One·Alicia López-de-EguiletaAlfonso Casado
Jan 10, 2018·Frontiers in Neurology·Jonah DoustarMaya Koronyo-Hamaoui
Apr 15, 2020·International Journal of Molecular Sciences·Francesca OppedisanoVincenzo Mollace
Dec 31, 2020·International Journal of Molecular Sciences·Umair ShabbirDeog-Hwan Oh
Oct 25, 2020·Medicina·Alicia López-de-EguiletaAlfonso Casado

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