Compounds from Kadsura heteroclita and related anti-HIV activity

Phytochemistry
Jian-Xin PuHan-Dong Sun

Abstract

Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipedlactone J (2), and two dibenzocyclooctadiene type lignans named heteroclitin I and J (3, 4). Compounds 8-10, 14, and 15 were weakly active as anti-HIV agents, whereas compounds 6 and 12 exhibited moderate anti-HIV activity with EC50 values of 1.6 microg/mL, and 1.4 microg/mL, therapeutic index (TI) values of 52.9, and 65.9, respectively. Their structures were established by spectroscopic methods, including application of 2D NMR techniques and CD spectra.

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Citations

Sep 30, 2008·Natural Product Reports·Wei-Lie XiaoHan-Dong Sun
Sep 26, 2009·Natural Product Reports·Reen-Yen KuoKuo-Hsiung Lee
Jun 17, 2010·Journal of Asian Natural Products Research·Guang-Yu YangHan-Dong Sun
Feb 3, 2012·Journal of Asian Natural Products Research·Xue-Mei GaoHan-Dong Sun
Mar 21, 2012·Journal of Asian Natural Products Research·Yong-Kuan ChenMing-Ming Miao
Nov 2, 2011·Chemical & Pharmaceutical Bulletin·Qiu-Fen HuGan-Peng Li
Jan 25, 2014·Bioorganic & Medicinal Chemistry·B Sathish KumarArvind S Negi
Oct 27, 2010·Natural Product Reports·Inder Pal Singh, Hardik S Bodiwala
Mar 4, 2010·Journal of Mass Spectrometry : JMS·Zhi-Jun WuGuo-Lin Zhang
Jan 21, 2014·Chemistry & Biodiversity·Jia ZhangChangqi Zhao
Jul 28, 2015·Journal of Natural Products·Cheng-Qin LiangHan-Dong Sun
May 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jiushi LiuPeigen Xiao
Mar 5, 2015·Bioorganic & Medicinal Chemistry Letters·Wei SuWei Wang
Dec 22, 2009·Natural Product Reports·Joseph D Connolly, Robert A Hill
Oct 30, 2016·Journal of Natural Products·Zheng-Xi HuHan-Dong Sun
May 2, 2017·Fitoterapia·Yuan-Qing LuoHan-Dong Sun
May 15, 2018·International Journal of Molecular Sciences·Bahare SalehiJavad Sharifi-Rad
Jun 12, 2020·Natural Product Research·Nuzhat ShehlaWei Wang
Jun 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiu-Shi LiuHai-Tao Liu
Aug 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yongbei LiuWei Wang
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang CaoWei Wang
Dec 29, 2020·Mitochondrial DNA. Part B, Resources·Qinghua WangYi Wang
Jan 23, 2021·Chemistry : a European Journal·Oliver Fischer, Markus R Heinrich
May 14, 2010·Journal of Natural Products·Guang-Yu YangHan-Dong Sun
Jul 23, 2020·Heliyon·Varittha SritalahareuthaiUthaiwan Suttisansanee
Dec 23, 2009·Journal of Natural Products·Jian-Hong YangHan-Dong Sun
Jun 8, 2021·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Xin-Ya XuHong-Jie Zhang

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