Compounds from Olea europaea and Pistacia lentiscus inhibit oral microbial growth

BMC Complementary and Alternative Medicine
Lamprini KarygianniAli Al-Ahmad

Abstract

In view of the increasing antibiotic resistance, the introduction of natural anti-infective agents has brought a new era in the treatment of bacterially derived oral diseases. The aim of this study was to investigate the antimicrobial potential of five natural constituents of Olea europaea (oleuropein, maslinic acid, hydroxytyrosol, oleocanthal, oleacein) and three compounds of Pistacia lentiscus (24Z-isomasticadienolic acid, oleanolic acid, oleanonic aldehyde) against ten representative oral bacterial species and a Candida albicans strain. After the isolation and quality control of natural compounds, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assay were performed. Among all O. europaea-derived constituents, maslinic acid was the most active (MIC = 4.9-312 μg mL- 1, MBC = 9.8-25 μg mL- 1) one against oral streptococci and anaerobic pathogenic bacteria (Porphyromonas gingivalis, Fusobacterium nucleatum, Parvimonas micra), while oleuropein, hydroxytyrosol, oleocanthal and oleacein showed milder, yet significant effects against P. gingivalis and F. nucleatum. Among all P. lentiscus compounds, oleanolic acid was the most effective one against almost all microorganisms with MIC values...Continue Reading

References

Feb 24, 2001·Planta medica·A BracaG Mazzanti
Jul 19, 2001·Nature·J L Dangl, J D Jones
May 4, 2002·Planta medica·Eva M Giner-LarzaJosé Luis Ríos
Jul 6, 2005·Current Opinion in Microbiology·Rudy Maor, Ken Shirasu
Nov 23, 2006·Antimicrobial Agents and Chemotherapy·Sotirios ParaschosAlexios-Leandros Skaltsounis
Dec 16, 2006·Nature Reviews. Microbiology·Tom J BattinLeo Eberl
Dec 12, 2007·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Luis C Scalon CunhaWilson R Cunha
Jun 23, 2009·Journal of Clinical Periodontology·Ioannis IoannidisAntonis Konstantinidis
Nov 18, 2009·Journal of Dental Research·S FilocheC H Sissons
Jan 30, 2010·International Journal of Molecular Sciences·Rocío González-LamotheKamal Bouarab
Feb 22, 2011·Applied Microbiology and Biotechnology·Tzi Bun NgHe Xiang Wang
Jun 8, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Ahmed TafeshHassan Azaizeh
Jan 3, 2012·Trends in Plant Science·Ishita AhujaAtle M Bones
Feb 22, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Anna KurekKrystyna I Wolska
Jul 19, 2012·World Journal of Microbiology & Biotechnology·M M SantosM E Pintado
Sep 13, 2012·Biochemical Pharmacology·Joshua D Chandler, Brian J Day
Oct 13, 2012·European Journal of Gastroenterology & Hepatology·Fernanda BritoCarlos M S Figueredo
Mar 2, 2013·Natural Product Reports·Linh T NgoWilliam R Folk
Jul 3, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Andrzej ParzonkoMarek Naruszewicz
Oct 26, 2013·Journal of Dental Research·S M DabdoubP S Kumar
Oct 31, 2013·European Journal of Nutrition·Annekathrin Martina KeilerMaria Halabalaki
Feb 12, 2014·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Fernanda Villas Boas PetroliniCarlos Henrique Gomes Martins
Feb 27, 2014·Journal of Natural Products·Konstantina VougogiannopoulouBrigitte Deguin
Mar 25, 2014·Archives of Biochemistry and Biophysics·Jörg FlemmigJürgen Arnhold
Jul 6, 2014·Annals of Clinical Microbiology and Antimicrobials·Carlo BisignanoGiuseppina Mandalari

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Methods Mentioned

BETA
column
Thin Layer Chromatography
column chromatography
nuclear magnetic resonance

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