Comprehensive analyses of how tubule occlusion and advanced glycation end-products diminish strength of aged dentin

Scientific Reports
Yuko ShinnoMikako Hayashi

Abstract

In clinical dentistry, since fracture is a major cause of tooth loss, better understanding of mechanical properties of teeth structures is important. Dentin, the major hard tissue of teeth, has similar composition to bone. In this study, we investigated the mechanical properties of human dentin not only in terms of mineral density but also using structural and quality parameters as recently accepted in evaluating bone strength. Aged crown and root dentin (age ≥ 40) exhibited significantly lower flexural strength and toughness than young dentin (age < 40). Aged dentin, in which the dentinal tubules were occluded with calcified material, recorded the highest mineral density; but showed significantly lower flexural strength than young dentin. Dentin with strong alignment of the c-axis in hydroxyapatite exhibited high fracture strength, possibly because the aligned apatite along the collagen fibrils may reinforce the intertubular dentin. Aged dentin, showing a high advanced glycation end-products (AGEs) level in its collagen, recorded low flexural strength. We first comprehensively identified significant factors, which affected the inferior mechanical properties of aged dentin. The low mechanical strength of aged dentin is caused b...Continue Reading

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Citations

Aug 3, 2018·International Journal of Legal Medicine·Aurora ValenzuelaBelén García-Villanova
Mar 20, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Masaaki KasaharaMasayuki Hattori
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May 20, 2021·Calcified Tissue International·Takuya IshimotoTakayoshi Nakano
Apr 13, 2021·Journal of Endodontics·Mohammad Ali SaghiriCraig Hirschberg

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