Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Shinya MaekawaNobuyuki Enomoto

Abstract

To comprehensively characterize the contribution of virological factors as well as interleukin-28B (IL28B) single-nucleotide polymorphisms (SNPs) in determining treatment responses in pegylated-interferon plus ribavirin (Peg-IFN/RBV) therapy for chronic hepatitis C virus (HCV)-1b infection, we undertook a retrospective cohort analysis for the pretreatment dominant complete HCV open reading frame (ORF) amino-acid (aa) sequence study in 103 consecutive HCV-1b Japanese patients. The dominant HCV sequences classified by the response were subjected to systematic sliding-window comparison analysis to characterize response-specific viral sequences, along with IL28B SNP analyses (rs8099917). In each comparison of the patients between with and without rapid viral response (RVR), nonearly viral response (nEVR), sustained virological response (SVR), or relapse, the following regions were extracted as most significantly associated with the different responses respectively: nonstructural protein 5A (NS5A) aa.2224-2248 (P = 1.2E-07); core aa.70 (P = 4E-04); NS5A aa.2340-2382 (P = 7.0E-08); and NS5A aa.2360-2377 (P = 1.1E-05). Those NS5A regions nearly coincided with the interferon (IFN) sensitivity-determining region (NS5A aa.2209-2248) and ...Continue Reading

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Citations

Jun 4, 2015·Emerging Microbes & Infections·Adrian EgliMichael Houghton
Mar 13, 2014·The Journal of Infectious Diseases·Adrian EgliAtul Humar
May 15, 2015·Journal of Medical Virology·Daniele Blasquez OlmedoLuís Cristóvão Porto
Oct 12, 2013·Pharmacotherapy·Marina Kawaguchi-Suzuki, Reginald F Frye
Mar 13, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mika MiuraNobuyuki Enomoto
Jan 13, 2015·Cytokine & Growth Factor Reviews·Guido AntonelliEnrico Proietti

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