Comprehensive analysis of circular RNAs in pathological states: biogenesis, cellular regulation, and therapeutic relevance

Cellular and Molecular Life Sciences : CMLS
Cornelia BraicuIoana Berindan-Neagoe

Abstract

Circular RNAs (circRNAs) are members of the non-coding transcriptome; however, some of them are translated into proteins. These transcripts have important roles in both physiological and pathological mechanisms due to their ability to directly influence cellular signaling pathways. Specifically, circRNAs are regulators of transcription, translation, protein interaction, and signal transduction. An increased knowledge within their area is observed over the last few years, concomitant with the development of next-generation sequencing techniques. circRNAs are mostly tissue and disease specific with the ability of specifically changing the biological behavior of cells. The altered expression profile is currently investigated as novel minimally invasive diagnosis/prognosis tool and also therapeutic target in human disease. The diagnosis approach is based on their level modification within pathological states, especially cancer, where circRNAs' therapies are intensively explored in anti-aging strategies, diabetes, cardiovascular diseases, and malignant pathologies, and are relying on the restoration of homeostatic profiles.

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Citations

Oct 28, 2019·Chinese Medical Journal·Dong LiXiao-Hua Zhu
May 6, 2019·Cancers·Cornelia BraicuIoana Berindan-Neagoe
Mar 18, 2020·Wiley Interdisciplinary Reviews. RNA·Rares DrulaIoana Berindan-Neagoe
Sep 26, 2020·Frontiers in Medicine·Malgorzata WygreckaKlaus T Preissner
Sep 5, 2019·International Journal of Molecular Sciences·Oana ZanoagaIoana Berindan-Neagoe
Mar 27, 2020·Frontiers in Cell and Developmental Biology·Anh M TranGeorge A Calin
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Fei LinGuoan Zhao
Aug 28, 2020·Frontiers in Microbiology·Javid Sadri NahandHamed Mirzaei
Sep 29, 2019·Molecular Aspects of Medicine·Diana GuleiIoana Berindan-Neagoe
Jan 24, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Qiwei YangBurton B Yang
Jan 30, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Rares DrulaIoana Berindan-Neagoe
Sep 10, 2019·Ecotoxicology and Environmental Safety·Daniela Eliza MarinIonelia Taranu
Jun 5, 2021·Archives of Physiology and Biochemistry·Sadra Samavarchi TehraniReza Meshkani
Jun 4, 2020·Aging and Disease·Cristina-Sorina CatanaIoana Berindan-Neagoe

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Methods Mentioned

BETA
electron
electrophoresis
nuclear translocation
RNAseq
CLIP-Seq

Clinical Trials Mentioned

NCT03334708

Software Mentioned

CircInteractome
find
StarBase
circANRIL
CircNet
circRNA
CIRI
CIRCexplorer
ElcircRNA
PcircRNA

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