Comprehensive analysis of dipeptides in alcoholic beverages by tag-based separation and determination using liquid chromatography/electrospray ionization tandem mass spectrometry and quadrupole-time-of-flight mass spectrometry

Journal of Chromatography. a
Kei TakahashiAkihiro Mizuno

Abstract

Fermented foods and beverages contain several different types of dipeptides, which are believed to be important components for taste. To date, however, a method for the comprehensive analysis of dipeptides in these products has not yet been established. In this study, comprehensive analysis of dipeptides in alcoholic beverages was performed by a high-resolution separation method based on the structural characteristics of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC)-derivatized dipeptides as well as dipeptide quantification and structural estimation using ultra-high-pressure liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) and UHPLC-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOFMS), respectively. Dipeptide content was found to differ considerably among Japanese sake, beer, and wine; UHPLC-MS/MS analysis revealed that many types of dipeptides are present in sake. Dipeptide quantification analysis identified 32 types of dipeptides within the concentration range of 1.1-97.2 μM in sake. The analysis was validated by dipeptide recovery of 64.0-107.2% (2.5 μM of standard) with a relative standard deviation of ≤33.2% from an actual alcoholic sample. Furthermore, UHPLC-Q-TOFMS analysis suggested the existe...Continue Reading

References

Nov 10, 2000·Journal of Chromatography. a·C DesportesF Duchiron
Dec 1, 2006·Functional & Integrative Genomics·Grant R CramerJohn C Cushman
Jan 28, 2009·Journal of Agricultural and Food Chemistry·Simone ToelstedeThomas Hofmann
Apr 3, 2009·Journal of Agricultural and Food Chemistry·Simone Toelstede, Thomas Hofmann
May 25, 2010·Journal of Food Science·Hanifah Nuryani LioeMasaaki Yasuda
Jul 14, 2010·Journal of Mass Spectrometry : JMS·Hisayuki HoraiTakaaki Nishioka
Mar 1, 2011·Journal of Chromatography. a·Georges Guiochon, Fabrice Gritti
Mar 5, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·G Fiechter, H K Mayer
Sep 29, 2011·Journal of Chromatography. a·Joséphine RutaDavy Guillarme

❮ Previous
Next ❯

Citations

Jan 19, 2016·Journal of Bioscience and Bioengineering·Masaki OkudaTakuro Ishii
Apr 16, 2015·Food Chemistry·Martina B O'Keeffe, Richard J FitzGerald
Oct 9, 2018·Bioscience, Biotechnology, and Biochemistry·Katsumi HashizumeTetsuo Tokiwano
Jun 27, 2020·Frontiers in Genetics·Carmen Becerra-RodríguezVirginie Galeote
Feb 8, 2019·Bioscience, Biotechnology, and Biochemistry·Masaki Okuda
Sep 5, 2020·Rapid Communications in Mass Spectrometry : RCM·Anne J KleinnijenhuisMaarten Hekman
Nov 2, 2019·Journal of Bioscience and Bioengineering·Katsumi HashizumeMasaki Okuda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.