Abstract
Liver cancer is the most common cancer and is the epitome of a recalcitrant cancer. Increasing evidence shown that long noncoding RNAs (lncRNA) were associated with cancer-related death and could function as a competing endogenous RNA (ceRNA). To explore regulatory roles and potential prognostic biomarkers of lncRNA for liver cancer, RNA-sequencing expression data were downloaded from the TCGA database and GEO database. A total of 357 patients were randomly divided into a discovery group and a validation group, of which 313 patients can obtain clinical data. In discovery phrase, 58 lncRNAs, 16 miRNAs, and 34 mRNAs were screened to construct the ceRNA network based on 252 patients employed from discovery group. Univariate and multivariate Cox hazard regression analysis model revealed that five lncRNAs (AATK-AS1, C10orf91, LINC00162, LINC00200, and LINC00501) from 58 lncRNAs were formulated to predict the overall survival (OS). We used the value of gene expression and regression coefficients to construct a risk score based on the five lncRNAs. Next, we validated our model in the GSE116174 dataset (n = 64) and the validation group (n = 94) from TCGA database. Subgroup analysis suggest that the five lncRNAs played critical parts in...Continue Reading
References
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Apr 21, 2009·Current Biology : CB·Hervé Seitz
Nov 11, 2009·PLoS Biology·David G HendricksonPatrick O Brown
Mar 23, 2011·Nature·Kevin C WangHoward Y Chang
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Nov 30, 2012·Nucleic Acids Research·Maria D ParaskevopoulouArtemis G Hatzigeorgiou
Mar 19, 2013·Cell·Tong Ihn Lee, Richard A Young
Aug 16, 2013·Current Pharmaceutical Design·Isabel FabregatPatricia Sancho
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Aug 16, 2014·Scientific Reports·Tian XiaJunming Guo
Mar 31, 2015·Nature Methods·Aaron M NewmanAsh A Alizadeh
Jan 23, 2016·Gastroenterology·Jordi BruixMorris Sherman
Apr 7, 2016·The Journal of Investigative Dermatology·Minna PiipponenVeli-Matti Kähäri
Nov 1, 2016·Nature Reviews. Microbiology·Lionello Bossi, Nara Figueroa-Bossi
Dec 14, 2016·PLoS Medicine·H Raza AliCarlos Caldas
May 31, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mingxing CuiXinli Zhan
Jul 27, 2017·OncoTargets and Therapy·Zhaoliang ChenJiaojiao Hu
Aug 19, 2017·Journal of Cancer·Ming LiYinping Lin
Aug 22, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinyan LiuZhihua Hou
Sep 25, 2017·Oral Oncology·Simin LiGerhard Schmalz
May 16, 2018·OncoTargets and Therapy·Qiaowei Fan, Bingrong Liu
Jul 5, 2018·The New England Journal of Medicine·Ghassan K Abou-AlfaRobin K Kelley
Sep 12, 2018·Aging·Ting LinQifei Wu
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 5, 2019·Cancer Medicine·Hui ZhangJifeng Feng
Feb 26, 2019·Nature Methods·Muthukumar RamanathanPaul A Khavari
Mar 15, 2019·Cell Death & Disease·Weijun WanXiufeng Ye
Mar 30, 2019·Gene·Liling DengFei Yang
Jun 28, 2019·Cancer Letters·Jiao ChenTao Tang
Citations
Jul 3, 2020·Aging·Zhongjing ZhangKeqing Shi
Aug 18, 2020·OncoTargets and Therapy·Ruo-Tian WangXiao-Gang Tan
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Zhengyan ChangHuanlong Qin
Dec 22, 2020·Frontiers in Cell and Developmental Biology·Ruyi HeYang Wang
Dec 8, 2020·BioMed Research International·Yifan ChenXudong Yao
Mar 17, 2021·Future Oncology·Yifang MaoMian He
Apr 7, 2021·Human Cell·Mengxin LinJie Pan
Aug 14, 2021·Oncology Letters·Zhou XuJianming Liao