Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients

Bioscience Reports
P RhoneDanuta Rość

Abstract

Thrombosis is one of the leading causes of mortality in cancer patients. The aim of the study was to evaluate the concentrations and activities of selected haemostatic parameters in the plasma of patients diagnosed with breast cancer (BrCa) and to make an attempt at finding associations with their levels and selected clinicopathological factors; clinical classification, histological grading, and molecular subtype of BrCa. The study involved 145 Caucasian ethnicity women. Eighty-five women aged 45-66 with primary BrCa without distant metastases (M0). Inclusion criteria were as follows: histopathological examination confirming the diagnosis of primary BrCa, without previous radiotherapy and chemotherapy. The control group consisted of 60, post-menopausal women, aged 45-68. Haemostatic profile expressed by concentrations and activities of tissue factor (TF) and its inhibitor (TFPI) as well as concentrations of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) were measured applying immunoassay techniques. A significantly higher concentration of PAI-1 was noted in patients with BrCa localized in the left breast. We observed significantly lower activity of TFPI and significantly higher concentrat...Continue Reading

References

Sep 14, 2007·Hematology·Soledad MolnarGustavo Jarchum
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jan 17, 2013·Journal of Hematology & Oncology·Benedicte StavikNina Iversen
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Begüm KocatürkHenri H Versteeg
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·B Kocatürk, H H Versteeg
Jul 31, 2013·Bioscience Reports·Luize G Lima, Robson Q Monteiro
Aug 3, 2013·Breast Cancer Research : BCR·Inder LalChris E Holmes
May 3, 2014·Thrombosis Research·Huda Omar AliGrethe Skretting
Nov 12, 2014·Molecular Medicine Reports·Lian Tao LiJun Nian Zheng
Nov 12, 2014·TheScientificWorldJournal·Songul Yasar YildizMehmet Agirbasli
May 10, 2017·Critical Reviews in Oncology/hematology·Branislav BystrickyMichal Mego
Aug 16, 2017·Blood·Yohei Hisada, Nigel Mackman

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Citations

May 30, 2020·International Journal of Oncology·Daniel L PouliquenCatherine Guette

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Methods Mentioned

BETA
blood collection
ELISA

Software Mentioned

Statistica

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