Comprehensive analysis of LDHAP5 pseudogene expression and potential pathogenesis in ovarian serous cystadenocarcinoma

Cancer Cell International
Shitong LinPeng Wu

Abstract

We aimed to identify differentially expressed pseudogenes and explore their potential functions in four types of common gynecological malignancies (e.g., cervical squamous cell carcinoma, ovarian serous cystadenocarcinoma, uterine corpus endometrial carcinoma, and uterine carcinosarcoma) using bioinformatics technology. We identified up-regulated and down-regulated pseudogenes and built a pseudogene-miRNA-mRNA regulatory network through public datasets to explore their potential functions in carcinogenesis and cancer prognosis. Among the 63 up-regulated pseudogenes identified, LDHAP5 demonstrated the greatest potential as a candidate pseudogene due to its significant association with poor overall survival in ovarian serous cystadenocarcinoma. KEGG pathway analysis revealed that LDHAP5 showed significant enrichment in MicroRNAs in cancer, Pathway in cancer and PI3K-AKT signaling pathway. Further analysis revealed that EGFR was the potential target mRNA of LDHAP5, which may play an important role in ovarian serous cystadenocarcinoma. LDHAP5 was associated with the occurrence and prognosis of ovarian serous cystadenocarcinoma, and thus shows potential as a novel therapeutic target against such cancer.

References

Sep 1, 1977·Cell·C JacqG G Brownlee
Jun 1, 1971·The Quarterly Review of Biology·R J Britten, E H Davidson
Jul 25, 1969·Science·R J Britten, E H Davidson
Feb 29, 2000·FEBS Letters·A J MighellA F Markham
Apr 25, 2001·Molecular Biology and Evolution·J O Andersson, S G Andersson
May 4, 2004·Oncogene·Mustapha KandouzGerald Batist
Sep 10, 2004·Briefings in Functional Genomics & Proteomics·Ilenia D'ErricoCecilia Saccone
Mar 16, 2007·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Apr 12, 2007·IUBMB Life·Wenyong DingJianwu Dai
Jul 8, 2008·Cancer Letters·Timothy K WilliamsJonathan Brody
Sep 5, 2009·Bioinformatics·Giovanni ScardoniCarlo Laudanna
Apr 20, 2010·Journal of Surgical Oncology·Christina FotopoulouJalid Sehouli
Mar 15, 2011·RNA·Ryan Charles PinkDavid Raul Francisco Carter
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Aug 6, 2011·Biochimie·Enrique M MuroMiguel A Andrade-Navarro
Nov 10, 2011·PLoS Biology·Michael P Eichenlaub, Laurence Ettwiller
Mar 3, 2012·Cancer Treatment Reviews·Ivan Diaz-PadillaAmit M Oza
Sep 20, 2012·Science Signaling·Laura Poliseno
Nov 8, 2013·BMC Evolutionary Biology·Luís Korrodi-GregórioPedro J Esteves
Oct 7, 2015·Frontiers in Medicine·Laura PolisenoPier Paolo Pandolfi
Dec 8, 2016·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Nov 11, 2017·Nucleic Acids Research·Chih-Hung ChouHsien-Da Huang
Aug 4, 2018·Cancers·Xinling HuYin-Yuan Mo
Sep 10, 2019·Cell Biology International·Feng ZhangYuzheng Zhuge
Nov 7, 2019·Nature Reviews. Cancer·Gerta Hoxhaj, Brendan D Manning
Nov 7, 2019·Seminars in Cancer Biology·Avaniyapuram Kannan Murugan
Dec 1, 2019·Journal of Cellular and Molecular Medicine·Xiao FuSong Zhao
Dec 19, 2019·Nature Reviews. Genetics·Seth W CheethamMarcel E Dinger

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-seq

Software Mentioned

Onco
STIRNG
OncoPrint
Centiscape
Print
cBioportal
GraphPad PRISM
Cytoscape
Bioportal
GEPIA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.